MacKenzie SJ - Search Results

1

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).

MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD. MacKenzie SJ, et al. Among authors: mackenzie c. Br J Pharmacol. 2002 Jun;136(3):421-33. doi: 10.1038/sj.bjp.0704743. Br J Pharmacol. 2002. PMID: 12023945 Free PMC article.

2

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

Hoffmann R, Baillie GS, MacKenzie SJ, Yarwood SJ, Houslay MD. Hoffmann R, et al. Among authors: mackenzie sj. EMBO J. 1999 Feb 15;18(4):893-903. doi: 10.1093/emboj/18.4.893. EMBO J. 1999. PMID: 10022832 Free PMC article.

3

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells.

MacKenzie SJ, Houslay MD. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8. doi: 10.1042/0264-6021:3470571. Biochem J. 2000. PMID: 10749688 Free PMC article.

4

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions.

MacKenzie SJ, Baillie GS, McPhee I, Bolger GB, Houslay MD. MacKenzie SJ, et al. J Biol Chem. 2000 Jun 2;275(22):16609-17. doi: 10.1074/jbc.275.22.16609. J Biol Chem. 2000. PMID: 10828059 Free article.

5

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases.

Baillie GS, MacKenzie SJ, McPhee I, Houslay MD. Baillie GS, et al. Among authors: mackenzie sj. Br J Pharmacol. 2000 Oct;131(4):811-9. doi: 10.1038/sj.bjp.0703636. Br J Pharmacol. 2000. PMID: 11030732 Free PMC article.

6

Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).

Baillie G, MacKenzie SJ, Houslay MD. Baillie G, et al. Among authors: mackenzie sj. Mol Pharmacol. 2001 Nov;60(5):1100-11. doi: 10.1124/mol.60.5.1100. Mol Pharmacol. 2001. PMID: 11641439

7

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

Scotland G, Beard M, Erdogan S, Huston E, McCallum F, MacKenzie SJ, Peden AH, Pooley L, Rena NG, Ross AH, Yarwood SJ, Houslay MD. Scotland G, et al. Among authors: mackenzie sj. Methods. 1998 Jan;14(1):65-79. doi: 10.1006/meth.1997.0566. Methods. 1998. PMID: 9500859

8

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.

MacKenzie SJ, Yarwood SJ, Peden AH, Bolger GB, Vernon RG, Houslay MD. MacKenzie SJ, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3549-54. doi: 10.1073/pnas.95.7.3549. Proc Natl Acad Sci U S A. 1998. PMID: 9520403 Free PMC article.

9

Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.

Houslay MD, Scotland G, Erdogan S, Huston E, Mackenzie S, McCallum JF, McPhee I, Pooley L, Rena G, Ross A, Beard M, Peder A, Begg F, Wilkinson I, Yarwood S, Ackerman C, Houslay ES, Hoffman R, Engels P, Sullivan M, Bolger G. Houslay MD, et al. Biochem Soc Trans. 1997 May;25(2):374-81. doi: 10.1042/bst0250374. Biochem Soc Trans. 1997. PMID: 9191121 Review. No abstract available.

10

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.

Gibson LC, Hastings SF, McPhee I, Clayton RA, Darroch CE, Mackenzie A, Mackenzie FL, Nagasawa M, Stevens PA, Mackenzie SJ. Gibson LC, et al. Among authors: mackenzie fl, mackenzie sj, mackenzie a. Eur J Pharmacol. 2006 May 24;538(1-3):39-42. doi: 10.1016/j.ejphar.2006.02.053. Epub 2006 Mar 13. Eur J Pharmacol. 2006. PMID: 16674936

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