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siRNA and innate immunity.
Robbins M, Judge A, MacLachlan I. Robbins M, et al. Among authors: maclachlan i. Oligonucleotides. 2009 Jun;19(2):89-102. doi: 10.1089/oli.2009.0180. Oligonucleotides. 2009. PMID: 19441890 Review.
Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.
Ma H, Dallas A, Ilves H, Shorenstein J, MacLachlan I, Klumpp K, Johnston BH. Ma H, et al. Among authors: maclachlan i. Gastroenterology. 2014 Jan;146(1):63-6.e5. doi: 10.1053/j.gastro.2013.09.049. Epub 2013 Sep 27. Gastroenterology. 2014. PMID: 24076507 Free PMC article.
Rational design of cationic lipids for siRNA delivery.
Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, Sah DW, Stebbing D, Crosley EJ, Yaworski E, Hafez IM, Dorkin JR, Qin J, Lam K, Rajeev KG, Wong KF, Jeffs LB, Nechev L, Eisenhardt ML, Jayaraman M, Kazem M, Maier MA, Srinivasulu M, Weinstein MJ, Chen Q, Alvarez R, Barros SA, De S, Klimuk SK, Borland T, Kosovrasti V, Cantley WL, Tam YK, Manoharan M, Ciufolini MA, Tracy MA, de Fougerolles A, MacLachlan I, Cullis PR, Madden TD, Hope MJ. Semple SC, et al. Among authors: maclachlan i. Nat Biotechnol. 2010 Feb;28(2):172-6. doi: 10.1038/nbt.1602. Epub 2010 Jan 17. Nat Biotechnol. 2010. PMID: 20081866
RNAi-mediated gene silencing in non-human primates.
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Röhl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat AJ, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher HP, MacLachlan I. Zimmermann TS, et al. Among authors: maclachlan i. Nature. 2006 May 4;441(7089):111-4. doi: 10.1038/nature04688. Epub 2006 Mar 26. Nature. 2006. PMID: 16565705
siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease.
Thi EP, Mire CE, Lee AC, Geisbert JB, Ursic-Bedoya R, Agans KN, Robbins M, Deer DJ, Cross RW, Kondratowicz AS, Fenton KA, MacLachlan I, Geisbert TW. Thi EP, et al. Among authors: maclachlan i. J Clin Invest. 2017 Dec 1;127(12):4437-4448. doi: 10.1172/JCI96185. Epub 2017 Nov 6. J Clin Invest. 2017. PMID: 29106386 Free PMC article.
Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA.
Thi EP, Lee AC, Geisbert JB, Ursic-Bedoya R, Agans KN, Robbins M, Deer DJ, Fenton KA, Kondratowicz AS, MacLachlan I, Geisbert TW, Mire CE. Thi EP, et al. Among authors: maclachlan i. Nat Microbiol. 2016 Aug 22;1(10):16142. doi: 10.1038/nmicrobiol.2016.142. Nat Microbiol. 2016. PMID: 27670117 Free PMC article.
Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates.
Thi EP, Mire CE, Lee AC, Geisbert JB, Zhou JZ, Agans KN, Snead NM, Deer DJ, Barnard TR, Fenton KA, MacLachlan I, Geisbert TW. Thi EP, et al. Among authors: maclachlan i. Nature. 2015 May 21;521(7552):362-5. doi: 10.1038/nature14442. Epub 2015 Apr 22. Nature. 2015. PMID: 25901685 Free PMC article.
Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA.
Thi EP, Mire CE, Ursic-Bedoya R, Geisbert JB, Lee ACH, Agans KN, Robbins M, Deer DJ, Fenton KA, MacLachlan I, Geisbert TW. Thi EP, et al. Among authors: maclachlan i. Sci Transl Med. 2014 Aug 20;6(250):250ra116. doi: 10.1126/scitranslmed.3009706. Sci Transl Med. 2014. PMID: 25143366 Free PMC article.
Protection against lethal Marburg virus infection mediated by lipid encapsulated small interfering RNA.
Ursic-Bedoya R, Mire CE, Robbins M, Geisbert JB, Judge A, MacLachlan I, Geisbert TW. Ursic-Bedoya R, et al. Among authors: maclachlan i. J Infect Dis. 2014 Feb 15;209(4):562-70. doi: 10.1093/infdis/jit465. Epub 2013 Aug 29. J Infect Dis. 2014. PMID: 23990568 Free PMC article.
Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation.
Robbins M, Judge A, Ambegia E, Choi C, Yaworski E, Palmer L, McClintock K, MacLachlan I. Robbins M, et al. Among authors: maclachlan i. Hum Gene Ther. 2008 Oct;19(10):991-9. doi: 10.1089/hum.2008.131. Hum Gene Ther. 2008. PMID: 18713023
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