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Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor.
Dunn C, Wiltshire C, MacLaren A, Gillespie DA. Dunn C, et al. Among authors: maclaren a. Cell Signal. 2002 Jul;14(7):585-93. doi: 10.1016/s0898-6568(01)00275-3. Cell Signal. 2002. PMID: 11955951 Review.
c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.
MacLaren A, Black EJ, Clark W, Gillespie DA. MacLaren A, et al. Mol Cell Biol. 2004 Oct;24(20):9006-18. doi: 10.1128/MCB.24.20.9006-9018.2004. Mol Cell Biol. 2004. PMID: 15456874 Free PMC article.
Cell transformation by v-Jun deactivates ERK MAP kinase signalling.
Black EJ, Walker M, Clark W, MacLaren A, Gillespie DA. Black EJ, et al. Among authors: maclaren a. Oncogene. 2002 Sep 19;21(42):6540-8. doi: 10.1038/sj.onc.1205851. Oncogene. 2002. PMID: 12226757
v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1.
Maclaren A, Clark W, Black EJ, Gregory D, Fujii H, Gillespie DA. Maclaren A, et al. Oncogene. 2003 Apr 24;22(16):2383-95. doi: 10.1038/sj.onc.1206329. Oncogene. 2003. PMID: 12717415
v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.
Clark W, Black EJ, MacLaren A, Kruse U, LaThangue N, Vogt PK, Gillespie DA. Clark W, et al. Among authors: maclaren a. Mol Cell Biol. 2000 Apr;20(7):2529-42. doi: 10.1128/mcb.20.7.2529-2542.2000. Mol Cell Biol. 2000. PMID: 10713176 Free PMC article.
v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release.
MacLaren A, Clark W, Gillespie DA. MacLaren A, et al. Oncogene. 2000 Nov 30;19(51):5906-18. doi: 10.1038/sj.onc.1203954. Oncogene. 2000. PMID: 11127822
Chk2 protects against radiation-induced genomic instability.
MacLaren A, Slavin D, McGowan CH. MacLaren A, et al. Radiat Res. 2009 Oct;172(4):463-72. doi: 10.1667/RR1603.1. Radiat Res. 2009. PMID: 19772467
p53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells.
MacLaren AP, Chapman RS, Wyllie AH, Watson CJ. MacLaren AP, et al. Cell Death Differ. 2001 Mar;8(3):210-8. doi: 10.1038/sj.cdd.4400801. Cell Death Differ. 2001. PMID: 11319603
Beatson International Cancer conference: genomic regulation and cancer.
Gordon KE, MacLaren AP, Barr NI. Gordon KE, et al. Among authors: maclaren ap. Br J Cancer. 2002 Mar 4;86(5):665-8. doi: 10.1038/sj.bjc.6600146. Br J Cancer. 2002. PMID: 11875722 Free PMC article.
Identification of transcripts showing differential expression in the developing mammary gland using differential display.
MacLaren AP, McBride D, Watson CJ, Clinton M. MacLaren AP, et al. Biochem Soc Trans. 1996 Aug;24(3):372S. doi: 10.1042/bst024372s. Biochem Soc Trans. 1996. PMID: 8878916 No abstract available.
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