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Pulmonary hypertension: therapeutic targets within the serotonin system.

Dempsie Y, MacLean MR. Dempsie Y, et al. Among authors: maclean mr. Br J Pharmacol. 2008 Oct;155(4):455-62. doi: 10.1038/bjp.2008.241. Epub 2008 Jun 9. Br J Pharmacol. 2008. PMID: 18536742 Free PMC article. Review.

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Influence of 2-Methoxyestradiol and Sex on Hypoxia-Induced Pulmonary Hypertension and Hypoxia-Inducible Factor-1-α.

Docherty CK, Nilsen M, MacLean MR. Docherty CK, et al. Among authors: maclean mr. J Am Heart Assoc. 2019 Mar 5;8(5):e011628. doi: 10.1161/JAHA.118.011628. J Am Heart Assoc. 2019. PMID: 30819028 Free PMC article.

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Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension.

Mair KM, Harvey KY, Henry AD, Hillyard DZ, Nilsen M, MacLean MR. Mair KM, et al. Among authors: maclean mr. Eur Respir J. 2019 Jun 13;53(6):1801524. doi: 10.1183/13993003.01524-2018. Print 2019 Jun. Eur Respir J. 2019. PMID: 30923189 Free PMC article.

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Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis.

White K, Dempsie Y, Caruso P, Wallace E, McDonald RA, Stevens H, Hatley ME, Van Rooij E, Morrell NW, MacLean MR, Baker AH. White K, et al. Among authors: maclean mr. Hypertension. 2014 Jul;64(1):185-94. doi: 10.1161/HYPERTENSIONAHA.113.03037. Epub 2014 Apr 14. Hypertension. 2014. PMID: 24732886

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Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

Ciuclan L, Hussey MJ, Burton V, Good R, Duggan N, Beach S, Jones P, Fox R, Clay I, Bonneau O, Konstantinova I, Pearce A, Rowlands DJ, Jarai G, Westwick J, MacLean MR, Thomas M. Ciuclan L, et al. Among authors: maclean mr. Am J Respir Crit Care Med. 2013 Jan 1;187(1):78-89. doi: 10.1164/rccm.201206-1028OC. Epub 2012 Oct 18. Am J Respir Crit Care Med. 2013. PMID: 23087024

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Cellular and molecular basis of pulmonary arterial hypertension.

Morrell NW, Adnot S, Archer SL, Dupuis J, Lloyd Jones P, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK. Morrell NW, et al. Among authors: maclean mr. J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S20-S31. doi: 10.1016/j.jacc.2009.04.018. J Am Coll Cardiol. 2009. PMID: 19555855 Free PMC article. Review.

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In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.

Morecroft I, Pang L, Baranowska M, Nilsen M, Loughlin L, Dempsie Y, Millet C, MacLean MR. Morecroft I, et al. Among authors: maclean mr. Cardiovasc Res. 2010 Feb 1;85(3):593-603. doi: 10.1093/cvr/cvp306. Epub 2009 Sep 7. Cardiovasc Res. 2010. PMID: 19736308

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Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease.

Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, Harmar AJ, Schmidt AM, Lukanidin E, Rabinovitch M. Lawrie A, et al. Among authors: maclean mr. Circ Res. 2005 Aug 5;97(3):227-35. doi: 10.1161/01.RES.0000176025.57706.1e. Epub 2005 Jul 7. Circ Res. 2005. PMID: 16002749

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Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice.

Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW. Long L, et al. Among authors: maclean mr. Circ Res. 2006 Mar 31;98(6):818-27. doi: 10.1161/01.RES.0000215809.47923.fd. Epub 2006 Feb 23. Circ Res. 2006. PMID: 16497988

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The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1.

Johansen AK, Dean A, Morecroft I, Hood K, Nilsen M, Loughlin L, Anagnostopoulou A, Touyz RM, White K, MacLean MR. Johansen AK, et al. Among authors: maclean mr. Pulm Circ. 2016 Mar;6(1):82-92. doi: 10.1086/685023. Pulm Circ. 2016. PMID: 27162617 Free PMC article.

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