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Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer.
Rochester MA, Riedemann J, Hellawell GO, Brewster SF, Macaulay VM. Rochester MA, et al. Among authors: macaulay vm. Cancer Gene Ther. 2005 Jan;12(1):90-100. doi: 10.1038/sj.cgt.7700775. Cancer Gene Ther. 2005. PMID: 15499378
Insulin-like growth factors and cancer.
Macaulay VM. Macaulay VM. Br J Cancer. 1992 Mar;65(3):311-20. doi: 10.1038/bjc.1992.65. Br J Cancer. 1992. PMID: 1313689 Free PMC article. Review. No abstract available.
A phase II study of bryostatin 1 in metastatic malignant melanoma.
Propper DJ, Macaulay V, O'Byrne KJ, Braybrooke JP, Wilner SM, Ganesan TS, Talbot DC, Harris AL. Propper DJ, et al. Among authors: macaulay v. Br J Cancer. 1998 Nov;78(10):1337-41. doi: 10.1038/bjc.1998.680. Br J Cancer. 1998. PMID: 9823975 Free PMC article. Clinical Trial.
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.
Playford MP, Bicknell D, Bodmer WF, Macaulay VM. Playford MP, et al. Among authors: macaulay vm. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12103-8. doi: 10.1073/pnas.210394297. Proc Natl Acad Sci U S A. 2000. PMID: 11035789 Free PMC article.
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase.
Macaulay VM, Salisbury AJ, Bohula EA, Playford MP, Smorodinsky NI, Shiloh Y. Macaulay VM, et al. Oncogene. 2001 Jul 5;20(30):4029-40. doi: 10.1038/sj.onc.1204565. Oncogene. 2001. PMID: 11494131
Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.
Hellawell GO, Turner GD, Davies DR, Poulsom R, Brewster SF, Macaulay VM. Hellawell GO, et al. Among authors: macaulay vm. Cancer Res. 2002 May 15;62(10):2942-50. Cancer Res. 2002. PMID: 12019176
The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript.
Bohula EA, Salisbury AJ, Sohail M, Playford MP, Riedemann J, Southern EM, Macaulay VM. Bohula EA, et al. Among authors: macaulay vm. J Biol Chem. 2003 May 2;278(18):15991-7. doi: 10.1074/jbc.M300714200. Epub 2003 Feb 24. J Biol Chem. 2003. PMID: 12604614
Targeting the type 1 insulin-like growth factor receptor as anti-cancer treatment.
Bohula EA, Playford MP, Macaulay VM. Bohula EA, et al. Among authors: macaulay vm. Anticancer Drugs. 2003 Oct;14(9):669-82. doi: 10.1097/00001813-200310000-00001. Anticancer Drugs. 2003. PMID: 14551500 Review.
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