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2,079 results
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Mitochondrial toxins and neurodegenerative diseases.
Ayala A, Venero JL, Cano J, Machado A. Ayala A, et al. Among authors: machado a. Front Biosci. 2007 Jan 1;12:986-1007. doi: 10.2741/2119. Front Biosci. 2007. PMID: 17127354 Review.
Dopamine-dependent neurotoxicity of lipopolysaccharide in substantia nigra.
De Pablos RM, Herrera AJ, Villarán RF, Cano J, Machado A. De Pablos RM, et al. Among authors: machado a. FASEB J. 2005 Mar;19(3):407-9. doi: 10.1096/fj.04-2153fje. Epub 2004 Dec 29. FASEB J. 2005. PMID: 15625078
Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood-brain barrier, and damage in the nigral dopaminergic system.
Tomás-Camardiel M, Rite I, Herrera AJ, de Pablos RM, Cano J, Machado A, Venero JL. Tomás-Camardiel M, et al. Among authors: machado a. Neurobiol Dis. 2004 Jun;16(1):190-201. doi: 10.1016/j.nbd.2004.01.010. Neurobiol Dis. 2004. PMID: 15207276
Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia.
Carreño-Müller E, Herrera AJ, de Pablos RM, Tomás-Camardiel M, Venero JL, Cano J, Machado A. Carreño-Müller E, et al. Among authors: machado a. J Neurochem. 2003 Mar;84(5):1201-14. doi: 10.1046/j.1471-4159.2003.01634.x. J Neurochem. 2003. PMID: 12603843
Decrease of 1-methyl-1,2,3,4-tetrahydroisoquinoline synthesizing enzyme activity in the brain areas of aged rat.
Absi E, Parrado J, Ayala A, Machado A. Absi E, et al. Among authors: machado a. Brain Res. 2002 Nov 15;955(1-2):161-3. doi: 10.1016/s0006-8993(02)03428-5. Brain Res. 2002. PMID: 12419532
Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not.
Santiago M, Hernández-Romero MC, Machado A, Cano J. Santiago M, et al. Among authors: machado a. Eur J Pharmacol. 2009 May 1;609(1-3):58-64. doi: 10.1016/j.ejphar.2009.03.026. Epub 2009 Mar 16. Eur J Pharmacol. 2009. PMID: 19292984
Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production.
Villarán RF, Tomás-Camardiel M, de Pablos RM, Santiago M, Herrera AJ, Navarro A, Machado A, Cano J. Villarán RF, et al. Among authors: machado a. Neurotoxicology. 2008 Mar;29(2):244-58. doi: 10.1016/j.neuro.2007.11.001. Epub 2007 Nov 17. Neurotoxicology. 2008. PMID: 18093658
Stress increases vulnerability to inflammation in the rat prefrontal cortex.
de Pablos RM, Villarán RF, Argüelles S, Herrera AJ, Venero JL, Ayala A, Cano J, Machado A. de Pablos RM, et al. Among authors: machado a. J Neurosci. 2006 May 24;26(21):5709-19. doi: 10.1523/JNEUROSCI.0802-06.2006. J Neurosci. 2006. PMID: 16723527 Free PMC article.
Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: evidence in Parkinson's disease patients.
Burguillos MA, Hajji N, Englund E, Persson A, Cenci AM, Machado A, Cano J, Joseph B, Venero JL. Burguillos MA, et al. Among authors: machado a. Neurobiol Dis. 2011 Jan;41(1):177-88. doi: 10.1016/j.nbd.2010.09.005. Epub 2010 Sep 17. Neurobiol Dis. 2011. PMID: 20850531
The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma.
Castaño A, Herrera AJ, Cano J, Machado A. Castaño A, et al. Among authors: machado a. J Neurochem. 2002 Apr;81(1):150-7. doi: 10.1046/j.1471-4159.2002.00799.x. J Neurochem. 2002. PMID: 12067227
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