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2020 1
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Paracetamol for low back pain.
Saragiotto BT, Machado GC, Ferreira ML, Pinheiro MB, Abdel Shaheed C, Maher CG. Saragiotto BT, et al. Among authors: machado gc. Cochrane Database Syst Rev. 2016 Jun 7;2016(6):CD012230. doi: 10.1002/14651858.CD012230. Cochrane Database Syst Rev. 2016. PMID: 27271789 Free PMC article. Review.
BACKGROUND: Analgesic medication is the most frequently prescribed treatment for low back pain (LBP), of which paracetamol (acetaminophen) is recommended as the first choice medication. However, there is uncertainty about the efficacy of paracetamol for LBP. …
BACKGROUND: Analgesic medication is the most frequently prescribed treatment for low back pain (LBP), of which paracetamol (acetam …
Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials.
Machado GC, Maher CG, Ferreira PH, Pinheiro MB, Lin CW, Day RO, McLachlan AJ, Ferreira ML. Machado GC, et al. BMJ. 2015 Mar 31;350:h1225. doi: 10.1136/bmj.h1225. BMJ. 2015. PMID: 25828856 Free PMC article. Review.
OBJECTIVE: To investigate the efficacy and safety of paracetamol (acetaminophen) in the management of spinal pain and osteoarthritis of the hip or knee. ...CONCLUSIONS: Paracetamol is ineffective in the treatment of low back pain and provides minimal short te …
OBJECTIVE: To investigate the efficacy and safety of paracetamol (acetaminophen) in the management of spinal pain and osteoart …
Paracetamol versus placebo for knee and hip osteoarthritis.
Leopoldino AO, Machado GC, Ferreira PH, Pinheiro MB, Day R, McLachlan AJ, Hunter DJ, Ferreira ML. Leopoldino AO, et al. Among authors: machado gc. Cochrane Database Syst Rev. 2019 Feb 25;2(2):CD013273. doi: 10.1002/14651858.CD013273. Cochrane Database Syst Rev. 2019. PMID: 30801133 Free PMC article.
BACKGROUND: Paracetamol (acetaminophen) is vastly recommended as the first-line analgesic for osteoarthritis of the hip or knee. ...None of the trials reported quality of life.Subgroup analyses indicated that the effects of paracetamol on pain and function di …
BACKGROUND: Paracetamol (acetaminophen) is vastly recommended as the first-line analgesic for osteoarthritis of the hip or kne …
Non-steroidal anti-inflammatory drugs for spinal pain: a systematic review and meta-analysis.
Machado GC, Maher CG, Ferreira PH, Day RO, Pinheiro MB, Ferreira ML. Machado GC, et al. Ann Rheum Dis. 2017 Jul;76(7):1269-1278. doi: 10.1136/annrheumdis-2016-210597. Epub 2017 Feb 2. Ann Rheum Dis. 2017. PMID: 28153830 Review.
BACKGROUND: While it is now clear that paracetamol is ineffective for spinal pain, there is not consensus on the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for this condition. ...
BACKGROUND: While it is now clear that paracetamol is ineffective for spinal pain, there is not consensus on the efficacy of non-ster …
Emergency department interventions for adult patients with low back pain: a systematic review of randomised controlled trials.
Oliveira CB, Amorim HE, Coombs DM, Richards B, Reedyk M, Maher CG, Machado GC. Oliveira CB, et al. Among authors: machado gc. Emerg Med J. 2021 Jan;38(1):59-68. doi: 10.1136/emermed-2020-209588. Epub 2020 Oct 9. Emerg Med J. 2021. PMID: 33037020
For those with sciatica (moderate quality evidence), intravenous paracetamol (acetaminophen) (MD -15.7, 95% CI -19.8 to -11.6) and intravenous morphine (MD -11.4, 95% CI -21.6 to -1.2) were both superior to placebo at 30 min. ...CONCLUSION: Ketoprofen gel for non-sp …
For those with sciatica (moderate quality evidence), intravenous paracetamol (acetaminophen) (MD -15.7, 95% CI -19.8 to -11.6) …