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Mitochondria in cancer: at the crossroads of life and death.
Fogg VC, Lanning NJ, Mackeigan JP. Fogg VC, et al. Among authors: mackeigan jp. Chin J Cancer. 2011 Aug;30(8):526-39. doi: 10.5732/cjc.011.10018. Chin J Cancer. 2011. PMID: 21801601 Free PMC article. Review.
Mitochondrial morphological features are associated with fission and fusion events.
Westrate LM, Drocco JA, Martin KR, Hlavacek WS, MacKeigan JP. Westrate LM, et al. Among authors: mackeigan jp. PLoS One. 2014 Apr 14;9(4):e95265. doi: 10.1371/journal.pone.0095265. eCollection 2014. PLoS One. 2014. PMID: 24733410 Free PMC article.
Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion. ...Of the features we evaluated, mitochondrial perimeter positively correlated with mitochondria about to undergo …
Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial …
Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.
Niemi NM, Lanning NJ, Westrate LM, MacKeigan JP. Niemi NM, et al. Among authors: mackeigan jp. PLoS One. 2013;8(1):e53803. doi: 10.1371/journal.pone.0053803. Epub 2013 Jan 10. PLoS One. 2013. PMID: 23326511 Free PMC article.
Protein Tyrosine Phosphatase localized to the Mitochondrion 1 (PTPMT1) is a dual specificity phosphatase exclusively localized to the mitochondria, and has recently been shown to be a critical component in the cardiolipin biosynthetic pathway. ...
Protein Tyrosine Phosphatase localized to the Mitochondrion 1 (PTPMT1) is a dual specificity phosphatase exclusively localized to the mit …
MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis.
Niemi NM, Lanning NJ, Klomp JA, Tait SW, Xu Y, Dykema KJ, Murphy LO, Gaither LA, Xu HE, Furge KA, Green DR, MacKeigan JP. Niemi NM, et al. Among authors: mackeigan jp. Mol Cell Biol. 2011 Apr;31(7):1357-68. doi: 10.1128/MCB.00788-10. Epub 2011 Jan 24. Mol Cell Biol. 2011. PMID: 21262771 Free PMC article.
MK-STYX was found to localize to the mitochondria but is neither released from the mitochondria upon apoptotic stress nor proximal to the machinery currently known to control MOMP, indicating that MK-STYX regulates MOMP using a distinct mechanism....
MK-STYX was found to localize to the mitochondria but is neither released from the mitochondria upon apoptotic stress nor prox …
A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.
Lanning NJ, Looyenga BD, Kauffman AL, Niemi NM, Sudderth J, DeBerardinis RJ, MacKeigan JP. Lanning NJ, et al. Among authors: mackeigan jp. Cell Rep. 2014 May 8;7(3):907-17. doi: 10.1016/j.celrep.2014.03.065. Epub 2014 Apr 24. Cell Rep. 2014. PMID: 24767988 Free PMC article.
Given this important link to human health, we sought to define proteins within mitochondria that are critical for maintaining homeostatic ATP levels. We screened an RNAi library targeting >1,000 nuclear-encoded genes whose protein products localize to the mitochondri …
Given this important link to human health, we sought to define proteins within mitochondria that are critical for maintaining homeost …
Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression.
Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, Méjean A, Vasiliu V, Richard S, MacKeigan JP, Teh BT, Furge KA. Klomp JA, et al. Among authors: mackeigan jp. BMC Med Genomics. 2010 Dec 16;3:59. doi: 10.1186/1755-8794-3-59. BMC Med Genomics. 2010. PMID: 21162720 Free PMC article.
The most prominent molecular feature of BHDS-derived kidney tumors was high expression of mitochondria-and oxidative phosphorylation (OXPHOS)-associated genes. This mitochondria expression phenotype was associated with deregulation of the PGC-1alpha-TFAM signaling a …
The most prominent molecular feature of BHDS-derived kidney tumors was high expression of mitochondria-and oxidative phosphorylation …