Mackey Z - Search Results

1

A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection.

Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. Ndao M, et al. Among authors: mackey z. Antimicrob Agents Chemother. 2013 Dec;57(12):6063-73. doi: 10.1128/AAC.00734-13. Epub 2013 Sep 23. Antimicrob Agents Chemother. 2013. PMID: 24060869 Free PMC article.

2

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. Among authors: mackey z. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

3

A parasite cysteine protease is key to host protein degradation and iron acquisition.

O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. O'Brien TC, et al. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18701454 Free PMC article.

4

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.

Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. Mackey ZB, et al. J Biol Chem. 2004 Nov 12;279(46):48426-33. doi: 10.1074/jbc.M402470200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326171 Free article.

5

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives.

Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R. Lavrado J, et al. Among authors: mackey z. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6256-60. doi: 10.1016/j.bmcl.2012.07.104. Epub 2012 Aug 15. Bioorg Med Chem Lett. 2012. PMID: 22926067

6

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.

Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. Abdulla MH, et al. PLoS Negl Trop Dis. 2008 Sep 24;2(9):e298. doi: 10.1371/journal.pntd.0000298. PLoS Negl Trop Dis. 2008. PMID: 18820745 Free PMC article.

7

High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei.

Mackey ZB, Koupparis K, Nishino M, McKerrow JH. Mackey ZB, et al. Chem Biol Drug Des. 2011 Sep;78(3):454-63. doi: 10.1111/j.1747-0285.2011.01156.x. Epub 2011 Jul 14. Chem Biol Drug Des. 2011. PMID: 21668652 Free PMC article.

8

Early invasion of brain parenchyma by African trypanosomes.

Frevert U, Movila A, Nikolskaia OV, Raper J, Mackey ZB, Abdulla M, McKerrow J, Grab DJ. Frevert U, et al. Among authors: mackey zb. PLoS One. 2012;7(8):e43913. doi: 10.1371/journal.pone.0043913. Epub 2012 Aug 31. PLoS One. 2012. PMID: 22952808 Free PMC article.

9

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Chen CK, et al. PLoS Negl Trop Dis. 2009;3(2):e372. doi: 10.1371/journal.pntd.0000372. Epub 2009 Feb 3. PLoS Negl Trop Dis. 2009. PMID: 19190730 Free PMC article.

10

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: mackey z. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

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