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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis.
Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I. Cai B, et al. Cell Metab. 2020 Feb 4;31(2):406-421.e7. doi: 10.1016/j.cmet.2019.11.013. Epub 2019 Dec 12. Cell Metab. 2020. PMID: 31839486 Free PMC article.
In humans, human genetic studies have shown that hypomorphic variations in MERTK, encoding the macrophage c-mer tyrosine kinase (MerTK) receptor, provide protection against liver fibrosis, but the mechanisms remain un …
In humans, human genetic studies have shown that hypomorphic variations in MERTK, encoding the macrophage c-mer …
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target.
Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, Coll M, Colell A, Gausdal G, Lorens JB, García de Frutos P, Morales A, Marí M. Tutusaus A, et al. Cell Mol Gastroenterol Hepatol. 2020;9(3):349-368. doi: 10.1016/j.jcmgh.2019.10.010. Epub 2019 Nov 2. Cell Mol Gastroenterol Hepatol. 2020. PMID: 31689560 Free PMC article.
BACKGROUND AND AIMS: GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. ...CONCLUSION: AXL signaling, increased in NASH patients, promotes fibrosis in HSCs and inflammation in KCs, …
BACKGROUND AND AIMS: GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver …
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators.
Pastore M, Caligiuri A, Raggi C, Navari N, Piombanti B, Di Maira G, Rovida E, Piccinni MP, Lombardelli L, Logiodice F, Rombouts K, Petta S, Marra F. Pastore M, et al. JHEP Rep. 2022 Feb 1;4(4):100444. doi: 10.1016/j.jhepr.2022.100444. eCollection 2022 Apr. JHEP Rep. 2022. PMID: 35252828 Free PMC article.
These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has …
These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the …
MERTK+/hi M2c Macrophages Induced by Baicalin Alleviate Non-Alcoholic Fatty Liver Disease.
Junior, Lai YS, Nguyen HT, Salmanida FP, Chang KT. Junior, et al. Int J Mol Sci. 2021 Sep 30;22(19):10604. doi: 10.3390/ijms221910604. Int J Mol Sci. 2021. PMID: 34638941 Free PMC article.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. ...Downregulation of cytokines and inflammation-associated genes, such as CCR5, may promote a pro-resolving milieu in the NAFLD liver. Alt …
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. ...Downregul …