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The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).
Br J Pharmacol. 2014 Jun;171(12):3051-64. doi: 10.1111/bph.12625.
Br J Pharmacol. 2014.
PMID: 24641614
Free PMC article.
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Hanke T, Dehm F, Liening S, Popella SD, Maczewsky J, Pillong M, Kunze J, Weinigel C, Barz D, Kaiser A, Wurglics M, Lämmerhofer M, Schneider G, Sautebin L, Schubert-Zsilavecz M, Werz O.
Hanke T, et al. Among authors: maczewsky j.
J Med Chem. 2013 Nov 27;56(22):9031-44. doi: 10.1021/jm401557w. Epub 2013 Nov 15.
J Med Chem. 2013.
PMID: 24171493
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The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism.
Maczewsky J, Sikimic J, Bauer C, Krippeit-Drews P, Wolke C, Lendeckel U, Barthlen W, Drews G.
Maczewsky J, et al.
Endocrinology. 2017 Jul 1;158(7):2145-2154. doi: 10.1210/en.2016-1941.
Endocrinology. 2017.
PMID: 28449117
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The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo.
Sahr A, Wolke C, Maczewsky J, Krippeit-Drews P, Tetzner A, Drews G, Venz S, Gürtler S, van den Brandt J, Berg S, Döring P, Dombrowski F, Walther T, Lendeckel U.
Sahr A, et al. Among authors: maczewsky j.
Endocrinology. 2016 Dec;157(12):4677-4690. doi: 10.1210/en.2016-1247. Epub 2016 Oct 7.
Endocrinology. 2016.
PMID: 27715254
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Approved LXR agonists exert unspecific effects on pancreatic β-cell function.
Maczewsky J, Kaiser J, Krippeit-Drews P, Drews G.
Maczewsky J, et al.
Endocrine. 2020 Jun;68(3):526-535. doi: 10.1007/s12020-020-02241-4. Epub 2020 Mar 7.
Endocrine. 2020.
PMID: 32146655
Free PMC article.
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TGR5 Activation Promotes Stimulus-Secretion Coupling of Pancreatic β-Cells via a PKA-Dependent Pathway.
Maczewsky J, Kaiser J, Gresch A, Gerst F, Düfer M, Krippeit-Drews P, Drews G.
Maczewsky J, et al.
Diabetes. 2019 Feb;68(2):324-336. doi: 10.2337/db18-0315. Epub 2018 Nov 8.
Diabetes. 2019.
PMID: 30409782
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PET/MRI enables simultaneous in vivo quantification of β-cell mass and function.
Michelotti FC, Bowden G, Küppers A, Joosten L, Maczewsky J, Nischwitz V, Drews G, Maurer A, Gotthardt M, Schmid AM, Pichler BJ.
Michelotti FC, et al. Among authors: maczewsky j.
Theranostics. 2020 Jan 1;10(1):398-410. doi: 10.7150/thno.33410. eCollection 2020.
Theranostics. 2020.
PMID: 31903128
Free PMC article.
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