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Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.
Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M, Orr C, McGarry T, Bombardieri M, Humby F, Proudman SM, Pitzalis C, Smith MD, Friedman JR, Anderson I, Madakamutil L, Veale DJ, Fearon U, Nagpal S. Guo Y, et al. Among authors: madakamutil l. PLoS One. 2018 Feb 28;13(2):e0192704. doi: 10.1371/journal.pone.0192704. eCollection 2018. PLoS One. 2018. PMID: 29489833 Free PMC article.
Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.
Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U, Pitzalis C, Humby F, Bombardieri M, Axel A, Adams H 3rd, Chiu C, Sharp M, Alvarez J, Anderson I, Madakamutil L, Nagpal S, Guo Y. Cole S, et al. Among authors: madakamutil l. Arthritis Res Ther. 2018 May 2;20(1):85. doi: 10.1186/s13075-018-1578-z. Arthritis Res Ther. 2018. PMID: 29720240 Free PMC article.
Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts.
Krishna V, Yin X, Song Q, Walsh A, Pocalyko D, Bachman K, Anderson I, Madakamutil L, Nagpal S. Krishna V, et al. Among authors: madakamutil l. J Immunol. 2021 Jan 15;206(2):422-431. doi: 10.4049/jimmunol.2000286. Epub 2020 Dec 7. J Immunol. 2021. PMID: 33288543
PD-L1- and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease.
Galea R, Nel HJ, Talekar M, Liu X, Ooi JD, Huynh M, Hadjigol S, Robson KJ, Ting YT, Cole S, Cochlin K, Hitchcock S, Zeng B, Yekollu S, Boks M, Goh N, Roberts H, Rossjohn J, Reid HH, Boyd BJ, Malaviya R, Shealy DJ, Baker DG, Madakamutil L, Kitching AR, O'Sullivan BJ, Thomas R. Galea R, et al. Among authors: madakamutil l. JCI Insight. 2019 Sep 19;4(18):e126025. doi: 10.1172/jci.insight.126025. JCI Insight. 2019. PMID: 31487265 Free PMC article.
Limited clonality in autoimmunity: drivers and regulators.
van den Elzen P, Menezes JS, Ametani A, Maverakis E, Madakamutil L, Tang XL, Kumar V, Sercarz EE. van den Elzen P, et al. Among authors: madakamutil l. Autoimmun Rev. 2004 Nov;3(7-8):524-9. doi: 10.1016/j.autrev.2004.07.008. Autoimmun Rev. 2004. PMID: 15546801
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