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The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.
Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T. Tsonkova VG, et al. Among authors: madsen d, madsen od. Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19. Mol Metab. 2018. PMID: 29307512 Free PMC article.
Semantic text mining in early drug discovery for type 2 diabetes.
Hansson LK, Hansen RB, Pletscher-Frankild S, Berzins R, Hansen DH, Madsen D, Christensen SB, Christiansen MR, Boulund U, Wolf XA, Kjærulff SK, van de Bunt M, Tulin S, Jensen TS, Wernersson R, Jensen JN. Hansson LK, et al. Among authors: madsen d. PLoS One. 2020 Jun 15;15(6):e0233956. doi: 10.1371/journal.pone.0233956. eCollection 2020. PLoS One. 2020. PMID: 32542027 Free PMC article.
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkjær SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, Nørgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, Jørgensen SB. Yang L, et al. Among authors: madsen d. Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846099
Construction of a versatile expression library for all human single-pass transmembrane proteins for receptor pairings by high throughput screening.
Yang W, Padkjær SB, Wang J, Sun Z, Shan B, Yang L, Chen H, Kang L, Madsen D, Li X, Shen C, Yu B, Zhu H, Chao TY, Cao Z, Li D, Liu W, Du Y, Xu J, Hao D, Xu F, Peng L, Li T, Wang L, Li L, Xing H, Liu D, Liu Z, Guan Z, Wang W, Cheng H, Østergaard H, Chang C, Yang Z, Boel E, Su J. Yang W, et al. Among authors: madsen d. J Biotechnol. 2017 Oct 20;260:18-30. doi: 10.1016/j.jbiotec.2017.08.023. Epub 2017 Sep 1. J Biotechnol. 2017. PMID: 28867483
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix.
Grahn E, Novotny M, Jakobsson E, Gustafsson A, Grehn L, Olin B, Madsen D, Wahlberg M, Mannervik B, Kleywegt GJ. Grahn E, et al. Among authors: madsen d. Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):197-207. doi: 10.1107/S0907444905039296. Epub 2006 Jan 18. Acta Crystallogr D Biol Crystallogr. 2006. PMID: 16421451
Evaluation of protein fold comparison servers.
Novotny M, Madsen D, Kleywegt GJ. Novotny M, et al. Among authors: madsen d. Proteins. 2004 Feb 1;54(2):260-70. doi: 10.1002/prot.10553. Proteins. 2004. PMID: 14696188
221 results