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Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, Rønn LC, Gether U. Thorsen TS, et al. Among authors: madsen kl. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. doi: 10.1073/pnas.0902225107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018661 Free PMC article.
Membrane localization is critical for activation of the PICK1 BAR domain.
Madsen KL, Eriksen J, Milan-Lobo L, Han DS, Niv MY, Ammendrup-Johnsen I, Henriksen U, Bhatia VK, Stamou D, Sitte HH, McMahon HT, Weinstein H, Gether U. Madsen KL, et al. Traffic. 2008 Aug;9(8):1327-43. doi: 10.1111/j.1600-0854.2008.00761.x. Epub 2008 May 8. Traffic. 2008. PMID: 18466293 Free PMC article.
How curved membranes recruit amphipathic helices and protein anchoring motifs.
Hatzakis NS, Bhatia VK, Larsen J, Madsen KL, Bolinger PY, Kunding AH, Castillo J, Gether U, Hedegård P, Stamou D. Hatzakis NS, et al. Among authors: madsen kl. Nat Chem Biol. 2009 Nov;5(11):835-41. doi: 10.1038/nchembio.213. Epub 2009 Sep 13. Nat Chem Biol. 2009. PMID: 19749743
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.
Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Bach A, et al. Among authors: madsen kl. Org Biomol Chem. 2010 Oct 7;8(19):4281-8. doi: 10.1039/c0ob00025f. Epub 2010 Jul 29. Org Biomol Chem. 2010. PMID: 20668766 Free PMC article.
210 results