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The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.
Gustafsen C, Kjolby M, Nyegaard M, Mattheisen M, Lundhede J, Buttenschøn H, Mors O, Bentzon JF, Madsen P, Nykjaer A, Glerup S. Gustafsen C, et al. Among authors: madsen p. Cell Metab. 2014 Feb 4;19(2):310-8. doi: 10.1016/j.cmet.2013.12.006. Cell Metab. 2014. PMID: 24506872
Human sorCS1 binds sortilin and hampers its cellular functions.
Larsen JV, Hermey G, Sørensen ES, Prabakaran T, Christensen EI, Gliemann J, Madsen P, Petersen CM. Larsen JV, et al. Among authors: madsen p. Biochem J. 2014 Jan 15;457(2):277-88. doi: 10.1042/BJ20130386. Biochem J. 2014. PMID: 24128306
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