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Mitochondrial function in normal and diabetic beta-cells.
Maechler P, Wollheim CB. Maechler P, et al. Nature. 2001 Dec 13;414(6865):807-12. doi: 10.1038/414807a. Nature. 2001. PMID: 11742413 Review.
Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.
Maechler P, Kennedy ED, Pozzan T, Wollheim CB. Maechler P, et al. EMBO J. 1997 Jul 1;16(13):3833-41. doi: 10.1093/emboj/16.13.3833. EMBO J. 1997. PMID: 9233793 Free PMC article.
Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase.
Maechler P, Wang H, Wollheim CB. Maechler P, et al. FEBS Lett. 1998 Feb 6;422(3):328-32. doi: 10.1016/s0014-5793(97)01618-9. FEBS Lett. 1998. PMID: 9498809
Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.
Kennedy ED, Maechler P, Wollheim CB. Kennedy ED, et al. Among authors: maechler p. Diabetes. 1998 Mar;47(3):374-80. doi: 10.2337/diabetes.47.3.374. Diabetes. 1998. PMID: 9519742
Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell.
Maechler P, Kennedy ED, Wang H, Wollheim CB. Maechler P, et al. J Biol Chem. 1998 Aug 14;273(33):20770-8. doi: 10.1074/jbc.273.33.20770. J Biol Chem. 1998. PMID: 9694821
Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.
Wang H, Maechler P, Hagenfeldt KA, Wollheim CB. Wang H, et al. Among authors: maechler p. EMBO J. 1998 Nov 16;17(22):6701-13. doi: 10.1093/emboj/17.22.6701. EMBO J. 1998. PMID: 9822613 Free PMC article.
Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell.
Maechler P, Wollheim CB. Maechler P, et al. Biofactors. 1998;8(3-4):255-62. doi: 10.1002/biof.5520080313. Biofactors. 1998. PMID: 9914827 Review.
Free radical modulation of insulin release in INS-1 cells exposed to alloxan.
Janjic D, Maechler P, Sekine N, Bartley C, Annen AS, Wolheim CB. Janjic D, et al. Among authors: maechler p. Biochem Pharmacol. 1999 Mar 15;57(6):639-48. doi: 10.1016/s0006-2952(98)00346-3. Biochem Pharmacol. 1999. PMID: 10037448
Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger.
Jornot L, Maechler P, Wollheim CB, Junod AF. Jornot L, et al. Among authors: maechler p. J Cell Sci. 1999 Apr;112 ( Pt 7):1013-22. J Cell Sci. 1999. PMID: 10198283
Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells.
Maechler P, Kennedy ED, Sebö E, Valeva A, Pozzan T, Wollheim CB. Maechler P, et al. J Biol Chem. 1999 Apr 30;274(18):12583-92. doi: 10.1074/jbc.274.18.12583. J Biol Chem. 1999. PMID: 10212237
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