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Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.
Donath MY, Størling J, Maedler K, Mandrup-Poulsen T. Donath MY, et al. Among authors: maedler k. J Mol Med (Berl). 2003 Aug;81(8):455-70. doi: 10.1007/s00109-003-0450-y. Epub 2003 Jul 18. J Mol Med (Berl). 2003. PMID: 12879149 Review.
Beta cells in type 2 diabetes - a crucial contribution to pathogenesis.
Maedler K. Maedler K. Diabetes Obes Metab. 2008 May;10(5):408-20. doi: 10.1111/j.1463-1326.2007.00718.x. Epub 2007 Apr 19. Diabetes Obes Metab. 2008. PMID: 17451426 Review.
Expression of Fas but not Fas ligand on fetal pig beta cells.
Bai L, Maedler K, Donath M, Tuch BE. Bai L, et al. Among authors: maedler k. Xenotransplantation. 2004 Sep;11(5):426-35. doi: 10.1111/j.1399-3089.2004.00158.x. Xenotransplantation. 2004. PMID: 15303979
Sulfonylurea induced beta-cell apoptosis in cultured human islets.
Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY. Maedler K, et al. J Clin Endocrinol Metab. 2005 Jan;90(1):501-6. doi: 10.1210/jc.2004-0699. Epub 2004 Oct 13. J Clin Endocrinol Metab. 2005. PMID: 15483097
Loss of beta-cell mass and function raises a concern regarding the application of sulfonylureas for the treatment of type 2 diabetes because previous studies have shown that agents that cause closure of inwardly rectifying K(+) sulfonylurea receptor subtype of ATP-sensitiv …
Loss of beta-cell mass and function raises a concern regarding the application of sulfonylureas for the treatment of type 2 diabetes because …
The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.
Brun T, Hu He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR. Brun T, et al. Among authors: maedler k. Hum Mol Genet. 2008 Feb 15;17(4):478-89. doi: 10.1093/hmg/ddm325. Epub 2007 Nov 7. Hum Mol Genet. 2008. PMID: 17989064
The Fas pathway is involved in pancreatic beta cell secretory function.
Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY. Schumann DM, et al. Among authors: maedler k. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. doi: 10.1073/pnas.0611487104. Epub 2007 Feb 13. Proc Natl Acad Sci U S A. 2007. PMID: 17299038 Free PMC article.
Mechanisms of beta-cell death in type 2 diabetes.
Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M. Donath MY, et al. Among authors: maedler k. Diabetes. 2005 Dec;54 Suppl 2:S108-13. doi: 10.2337/diabetes.54.suppl_2.s108. Diabetes. 2005. PMID: 16306327 Review.
With respect to these causal factors, we focus on Fas, the ATP-sensitive K+ channel, insulin receptor substrate 2, oxidative stress, nuclear factor-kappaB, endoplasmic reticulum stress, and mitochondrial dysfunction as their respective mechanisms of action. ...
With respect to these causal factors, we focus on Fas, the ATP-sensitive K+ channel, insulin receptor substrate 2, oxidative stress, …
Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways.
Hammar E, Parnaud G, Bosco D, Perriraz N, Maedler K, Donath M, Rouiller DG, Halban PA. Hammar E, et al. Among authors: maedler k. Diabetes. 2004 Aug;53(8):2034-41. doi: 10.2337/diabetes.53.8.2034. Diabetes. 2004. PMID: 15277383
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY. Maedler K, et al. Diabetes. 2004 Jul;53(7):1706-13. doi: 10.2337/diabetes.53.7.1706. Diabetes. 2004. PMID: 15220194
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.
Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY. Maedler K, et al. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. doi: 10.1073/pnas.0305683101. Epub 2004 May 12. Proc Natl Acad Sci U S A. 2004. PMID: 15141093 Free PMC article.
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