Maedler K - Search Results

1

Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2.

Yuan T, Gorrepati KD, Maedler K, Ardestani A. Yuan T, et al. Among authors: maedler k. Cell Death Dis. 2016 Feb 18;7(2):e2107. doi: 10.1038/cddis.2016.21. Cell Death Dis. 2016. PMID: 26890146 Free PMC article. No abstract available.

2

Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets.

Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K. Shu L, et al. Among authors: maedler k. Diabetes. 2008 Mar;57(3):645-53. doi: 10.2337/db07-0847. Epub 2007 Dec 10. Diabetes. 2008. PMID: 18071026 Retracted.

3

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.

Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R. Maedler K, et al. FASEB J. 2008 Jun;22(6):1905-13. doi: 10.1096/fj.07-101824. Epub 2008 Feb 8. FASEB J. 2008. PMID: 18263705

4

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.

Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, Bhushan A, Maedler K. Schulthess FT, et al. Among authors: maedler k. PLoS One. 2009;4(2):e4394. doi: 10.1371/journal.pone.0004394. Epub 2009 Feb 6. PLoS One. 2009. PMID: 19197367 Free PMC article.

5

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K. Shu L, et al. Among authors: maedler k. Hum Mol Genet. 2009 Jul 1;18(13):2388-99. doi: 10.1093/hmg/ddp178. Epub 2009 Apr 21. Hum Mol Genet. 2009. PMID: 19386626 Free PMC article.

6

Interleukin-1 beta targeted therapy for type 2 diabetes.

Maedler K, Dharmadhikari G, Schumann DM, Størling J. Maedler K, et al. Expert Opin Biol Ther. 2009 Sep;9(9):1177-88. doi: 10.1517/14712590903136688. Expert Opin Biol Ther. 2009. PMID: 19604125 Review.

7

CXCL10- a path to β-cell death.

Paroni F, Domsgen E, Maedler K. Paroni F, et al. Among authors: maedler k. Islets. 2009 Nov-Dec;1(3):256-9. doi: 10.4161/isl.1.3.9110. Islets. 2009. PMID: 21099280

8

Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes.

Maedler K, Dharmadhikari G, Schumann DM, Størling J. Maedler K, et al. Handb Exp Pharmacol. 2011;(203):257-78. doi: 10.1007/978-3-642-17214-4_11. Handb Exp Pharmacol. 2011. PMID: 21484575 Review.

9

TCF7L2 promotes beta cell regeneration in human and mouse pancreas.

Shu L, Zien K, Gutjahr G, Oberholzer J, Pattou F, Kerr-Conte J, Maedler K. Shu L, et al. Among authors: maedler k. Diabetologia. 2012 Dec;55(12):3296-307. doi: 10.1007/s00125-012-2693-z. Epub 2012 Sep 4. Diabetologia. 2012. PMID: 22945304

10

The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization.

Shah P, Ardestani A, Dharmadhikari G, Laue S, Schumann DM, Kerr-Conte J, Pattou F, Klein T, Maedler K. Shah P, et al. Among authors: maedler k. J Clin Endocrinol Metab. 2013 Jul;98(7):E1163-72. doi: 10.1210/jc.2013-1029. Epub 2013 Apr 30. J Clin Endocrinol Metab. 2013. PMID: 23633194

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