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Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL.
Szegezdi E, van der Sloot AM, Mahalingam D, O'Leary L, Cool RH, Muñoz IG, Montoya G, Quax WJ, de Jong S, Samali A, Serrano L. Szegezdi E, et al. Among authors: mahalingam d. Mol Cell Proteomics. 2012 Mar;11(3):M111.013730. doi: 10.1074/mcp.M111.013730. Epub 2012 Jan 2. Mol Cell Proteomics. 2012. PMID: 22213832 Free PMC article.
Targeting TRAIL towards the clinic.
Mahalingam D, Oldenhuis CN, Szegezdi E, Giles FJ, de Vries EG, de Jong S, Nawrocki ST. Mahalingam D, et al. Curr Drug Targets. 2011 Dec;12(14):2079-90. doi: 10.2174/138945011798829357. Curr Drug Targets. 2011. PMID: 21777191
Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model.
Duiker EW, de Vries EG, Mahalingam D, Meersma GJ, Boersma-van Ek W, Hollema H, Lub-de Hooge MN, van Dam GM, Cool RH, Quax WJ, Samali A, van der Zee AG, de Jong S. Duiker EW, et al. Among authors: mahalingam d. Clin Cancer Res. 2009 Mar 15;15(6):2048-57. doi: 10.1158/1078-0432.CCR-08-1535. Epub 2009 Mar 10. Clin Cancer Res. 2009. PMID: 19276284 Free article.
Targeting HSP90 for cancer therapy.
Mahalingam D, Swords R, Carew JS, Nawrocki ST, Bhalla K, Giles FJ. Mahalingam D, et al. Br J Cancer. 2009 May 19;100(10):1523-9. doi: 10.1038/sj.bjc.6605066. Epub 2009 Apr 28. Br J Cancer. 2009. PMID: 19401686 Free PMC article. Review.
111 results