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Long-term outcome of liver transplantation in patients with PSC: a comparative analysis with PBC.
Maheshwari A, Yoo HY, Thuluvath PJ. Maheshwari A, et al. Am J Gastroenterol. 2004 Mar;99(3):538-42. doi: 10.1111/j.1572-0241.2004.04050.x. Am J Gastroenterol. 2004. PMID: 15056099
In this study, we compared 10-yr survival of patients with PSC and PBC using a large database after adjusting for other confounding risk factors. ...CONCLUSIONS: Patients with PSC had a higher retransplantation rate and lower survival when compared to PBC. Based on …
In this study, we compared 10-yr survival of patients with PSC and PBC using a large database after adjusting for other confounding r …
Retransplantation of liver: primary graft nonfunction and hepatitis C virus are associated with worse outcome.
Yoo HY, Maheshwari A, Thuluvath PJ. Yoo HY, et al. Liver Transpl. 2003 Sep;9(9):897-904. doi: 10.1053/jlts.2003.50176. Liver Transpl. 2003. PMID: 12942450
There was a greater incidence of PGNF (9.4% v 4.0%; P <.001) and regrafting (23.1% v 7.4%; P <.001) in the re-LT groups compared with the PLT group. ...Re-LT was associated with a greater rate of complications and lower patient and graft survival compared with …
There was a greater incidence of PGNF (9.4% v 4.0%; P <.001) and regrafting (23.1% v 7.4%; P <.001) in the re-LT groups compare …
Randomised, double blind, placebo controlled trial of interferon, ribavirin, and amantadine versus interferon, ribavirin, and placebo in treatment naïve patients with chronic hepatitis C.
Thuluvath PJ, Maheshwari A, Mehdi J, Fairbanks KD, Wu LL, Gelrud LG, Ryan MJ, Anania FA, Lobis IF, Black M. Thuluvath PJ, et al. Gut. 2004 Jan;53(1):130-5. doi: 10.1136/gut.53.1.130. Gut. 2004. PMID: 14684587 Free PMC article. Clinical Trial.
METHODS: In this prospective, randomised, double blind, placebo controlled, multicentre study, 85 patients (amantadine group) received a three drug regimen of interferon alfa-2b 3 million units three times per week, ribavirin 1000-1200 mg daily in divided doses, and amanta …
METHODS: In this prospective, randomised, double blind, placebo controlled, multicentre study, 85 patients (amantadine group) received a
Post-liver-transplant anemia: etiology and management.
Maheshwari A, Mishra R, Thuluvath PJ. Maheshwari A, et al. Liver Transpl. 2004 Feb;10(2):165-73. doi: 10.1002/lt.20031. Liver Transpl. 2004. PMID: 14762852 Review.
Aplastic anemia is seen in young patients transplanted for non-A, non-B, non-C, fulminant hepatic failure. It is thought to be immunologically mediated, secondary to an unknown viral infection, and is associated with a grave prognosis. GVHD is another infrequent (ap …
Aplastic anemia is seen in young patients transplanted for non-A, non-B, non-C, fulminant hepatic failure. It is thought to be immuno …
Patients with autonomic neuropathy are more likely to develop hepatic encephalopathy.
Maheshwari A, Thomas A, Thuluvath PJ. Maheshwari A, et al. Dig Dis Sci. 2004 Oct;49(10):1584-8. doi: 10.1023/b:ddas.0000043368.73042.b0. Dig Dis Sci. 2004. PMID: 15573909
Of the 72 patients, 42 (58%) patients did not develop HE (group A) while 30 (42%) developed HE (group B) during the follow-up. ...AN was more common in group B (27/30; 90%) compared to group A (28/42; 67%) (P = 0.02). Kaplan-Meier analysis showed a trend towa …
Of the 72 patients, 42 (58%) patients did not develop HE (group A) while 30 (42%) developed HE (group B) during the follow-up. ...AN …
A randomized controlled trial of beta-blockers versus endoscopic band ligation for primary prophylaxis: a large sample size is required to show a difference in bleeding rates.
Thuluvath PJ, Maheshwari A, Jagannath S, Arepally A. Thuluvath PJ, et al. Dig Dis Sci. 2005 Feb;50(2):407-10. doi: 10.1007/s10620-005-1619-8. Dig Dis Sci. 2005. PMID: 15745109 Clinical Trial.
At the time of termination, 31 patients (Child A, 11; B, 14; C, 6), with a mean HVWPG of 19 +/- 9.1 mm Hg, were randomized to either band ligation (group A; n = 16) or beta-blockers (group B; n = 15). ...During the follow-up, two patients in group A an …
At the time of termination, 31 patients (Child A, 11; B, 14; C, 6), with a mean HVWPG of 19 +/- 9.1 mm Hg, were randomized to …
Autonomic neuropathy may be associated with delayed orocaecal transit time in patients with cirrhosis.
Maheshwari A, Thuluvath PJ. Maheshwari A, et al. Auton Neurosci. 2005 Mar 31;118(1-2):135-9. doi: 10.1016/j.autneu.2005.02.003. Auton Neurosci. 2005. PMID: 15795187
METHODS: We determined OCT and autonomic function tests (AFT) in 48 patients (Child A-15, B-27, C-6) with cirrhosis of various aetiologies. ...OCT was defined as the time from baseline when there was a rise in H2 levels of >20 ppm over baseline or >10 ppm over …
METHODS: We determined OCT and autonomic function tests (AFT) in 48 patients (Child A-15, B-27, C-6) with cirrhosis of various aetiol …
Cryptogenic cirrhosis and NAFLD: are they related?
Maheshwari A, Thuluvath PJ. Maheshwari A, et al. Am J Gastroenterol. 2006 Mar;101(3):664-8. doi: 10.1111/j.1572-0241.2006.00478.x. Epub 2006 Feb 8. Am J Gastroenterol. 2006. PMID: 16464222
Cryptogenic cirrhosis (CC), literally meaning cirrhosis of obscure or unknown origin, is a diagnosis of exclusion. The circumstantial evidence indicates that nonalcoholic fatty liver disease (NAFLD) is perhaps one of the important causes of CC. ...Other rare causes may inc …
Cryptogenic cirrhosis (CC), literally meaning cirrhosis of obscure or unknown origin, is a diagnosis of exclusion. The circumstantial …
Oral V2 receptor antagonist (RWJ-351647) in patients with cirrhosis and ascites: a randomized, double-blind, placebo-controlled, single ascending dose study.
Thuluvath PJ, Maheshwari A, Wong F, Yoo HW, Schrier RW, Parikh C, Steare S, Korula J. Thuluvath PJ, et al. Aliment Pharmacol Ther. 2006 Sep 15;24(6):973-82. doi: 10.1111/j.1365-2036.2006.03088.x. Aliment Pharmacol Ther. 2006. PMID: 16948809 Clinical Trial.
Increases in cumulative urine volume and free water excretion, and a decrease in urine osmolality were noted in a dose-dependent manner reaching the statistical significance at the 5-mg dose. Four patients exhibited a decrease of > 2 kg in weight in the 24 …
Increases in cumulative urine volume and free water excretion, and a decrease in urine osmolality were noted in a dose-depende …
Sirolimus monotherapy versus sirolimus in combination with steroids and/or MMF for immunosuppression after liver transplantation.
Maheshwari A, Torbenson MS, Thuluvath PJ. Maheshwari A, et al. Dig Dis Sci. 2006 Oct;51(10):1677-84. doi: 10.1007/s10620-005-9026-8. Dig Dis Sci. 2006. PMID: 16964550
Calcineurin inhibitor (CI)-associated renal dysfunction has emerged as a major cause of morbidity and mortality after liver transplantation. ...Seven (11.3%) patients experienced acute rejection (Group A, two; Group B, five; P = NS) and this resulted in the disconti …
Calcineurin inhibitor (CI)-associated renal dysfunction has emerged as a major cause of morbidity and mortality after liver transplan …
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