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Azacytidine causes complex DNA methylation responses in myeloid leukemia.
Stresemann C, Bokelmann I, Mahlknecht U, Lyko F. Stresemann C, et al. Mol Cancer Ther. 2008 Sep;7(9):2998-3005. doi: 10.1158/1535-7163.MCT-08-0411. Mol Cancer Ther. 2008. PMID: 18790780 Clinical Trial.
VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells.
Essa S, Denzer N, Mahlknecht U, Klein R, Collnot EM, Tilgen W, Reichrath J. Essa S, et al. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):110-3. doi: 10.1016/j.jsbmb.2010.02.003. Epub 2010 Feb 11. J Steroid Biochem Mol Biol. 2010. PMID: 20153427
Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group.
Heilig CE, Löffler H, Mahlknecht U, Janssen JW, Ho AD, Jauch A, Krämer A. Heilig CE, et al. J Cell Mol Med. 2010 Apr;14(4):895-902. doi: 10.1111/j.1582-4934.2009.00905.x. Epub 2009 Sep 14. J Cell Mol Med. 2010. PMID: 19754665 Free PMC article.
The T_T genotype within the NME1 promoter single nucleotide polymorphism -835 C/T is associated with an increased risk of cytarabine induced neurotoxicity in patients with acute myeloid leukemia.
Braunagel D, Schaich M, Kramer M, Dransfeld CL, Ehninger G, Mahlknecht U. Braunagel D, et al. Leuk Lymphoma. 2012 May;53(5):952-7. doi: 10.3109/10428194.2011.635862. Epub 2011 Dec 7. Leuk Lymphoma. 2012. PMID: 22035418 Clinical Trial.
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis.
Fas SC, Baumann S, Zhu JY, Giaisi M, Treiber MK, Mahlknecht U, Krammer PH, Li-Weber M. Fas SC, et al. Blood. 2006 Dec 1;108(12):3700-6. doi: 10.1182/blood-2006-03-011973. Epub 2006 Aug 24. Blood. 2006. PMID: 16931628
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities.
Zhu JY, Lavrik IN, Mahlknecht U, Giaisi M, Proksch P, Krammer PH, Li-Weber M. Zhu JY, et al. Int J Cancer. 2007 Oct 15;121(8):1839-46. doi: 10.1002/ijc.22883. Int J Cancer. 2007. PMID: 17565740
GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.
Fabian J, Lodrini M, Oehme I, Schier MC, Thole TM, Hielscher T, Kopp-Schneider A, Opitz L, Capper D, von Deimling A, Wiegand I, Milde T, Mahlknecht U, Westermann F, Popanda O, Roels F, Hero B, Berthold F, Fischer M, Kulozik AE, Witt O, Deubzer HE. Fabian J, et al. Among authors: mahlknecht u. Cancer Res. 2014 May 1;74(9):2604-16. doi: 10.1158/0008-5472.CAN-13-1904. Epub 2014 Jan 13. Cancer Res. 2014. PMID: 24419085 Free article.
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