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The nasal approach to delivering treatment for brain diseases: an anatomic, physiologic, and delivery technology overview.
Djupesland PG, Messina JC, Mahmoud RA. Djupesland PG, et al. Among authors: mahmoud ra. Ther Deliv. 2014 Jun;5(6):709-33. doi: 10.4155/tde.14.41. Ther Deliv. 2014. PMID: 25090283 Review.
Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial.
Quintana DS, Westlye LT, Alnæs D, Rustan ØG, Kaufmann T, Smerud KT, Mahmoud RA, Djupesland PG, Andreassen OA. Quintana DS, et al. Among authors: mahmoud ra. Psychoneuroendocrinology. 2016 Jul;69:180-8. doi: 10.1016/j.psyneuen.2016.04.010. Epub 2016 Apr 22. Psychoneuroendocrinology. 2016. PMID: 27107209 Clinical Trial.
Accessing the brain: the nose may know the way.
Djupesland PG, Mahmoud RA, Messina JC. Djupesland PG, et al. Among authors: mahmoud ra. J Cereb Blood Flow Metab. 2013 May;33(5):793-4. doi: 10.1038/jcbfm.2013.41. Epub 2013 Mar 13. J Cereb Blood Flow Metab. 2013. PMID: 23486291 Free PMC article. No abstract available.
NAVIGATE II: Randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis.
Leopold DA, Elkayam D, Messina JC, Kosik-Gonzalez C, Djupesland PG, Mahmoud RA. Leopold DA, et al. Among authors: mahmoud ra. J Allergy Clin Immunol. 2019 Jan;143(1):126-134.e5. doi: 10.1016/j.jaci.2018.06.010. Epub 2018 Jun 19. J Allergy Clin Immunol. 2019. PMID: 29928924 Clinical Trial.
Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study.
Quintana DS, Westlye LT, Alnæs D, Kaufmann T, Mahmoud RA, Smerud KT, Djupesland PG, Andreassen OA. Quintana DS, et al. Among authors: mahmoud ra. Neuropsychopharmacology. 2019 Jan;44(2):306-313. doi: 10.1038/s41386-018-0241-3. Epub 2018 Oct 16. Neuropsychopharmacology. 2019. PMID: 30323359 Free PMC article. Clinical Trial.
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men.
Quintana DS, Westlye LT, Smerud KT, Mahmoud RA, Andreassen OA, Djupesland PG. Quintana DS, et al. Among authors: mahmoud ra. Horm Behav. 2018 Jun;102:85-92. doi: 10.1016/j.yhbeh.2018.05.004. Epub 2018 May 16. Horm Behav. 2018. PMID: 29750971 Clinical Trial.
Early Onset of Efficacy and Consistency of Response Across Multiple Migraine Attacks From the Randomized COMPASS Study: AVP-825 Breath Powered® Exhalation Delivery System (Sumatriptan Nasal Powder) vs Oral Sumatriptan.
Silberstein S, Winner PK, McAllister PJ, Tepper SJ, Halker R, Mahmoud RA, Siffert J. Silberstein S, et al. Among authors: mahmoud ra. Headache. 2017 Jun;57(6):862-876. doi: 10.1111/head.13105. Epub 2017 May 11. Headache. 2017. PMID: 28497569 Clinical Trial.
AVP-825 breath-powered intranasal delivery system containing 22 mg sumatriptan powder vs 100 mg oral sumatriptan in the acute treatment of migraines (The COMPASS study): a comparative randomized clinical trial across multiple attacks.
Tepper SJ, Cady RK, Silberstein S, Messina J, Mahmoud RA, Djupesland PG, Shin P, Siffert J. Tepper SJ, et al. Among authors: mahmoud ra. Headache. 2015 May;55(5):621-35. doi: 10.1111/head.12583. Epub 2015 May 4. Headache. 2015. PMID: 25941016 Free PMC article. Clinical Trial.
Breath powered nasal delivery: a new route to rapid headache relief.
Djupesland PG, Messina JC, Mahmoud RA. Djupesland PG, et al. Among authors: mahmoud ra. Headache. 2013 Sep;53 Suppl 2:72-84. doi: 10.1111/head.12186. Headache. 2013. PMID: 24024605 Free PMC article. Review.
Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment.
Quintana DS, Westlye LT, Rustan ØG, Tesli N, Poppy CL, Smevik H, Tesli M, Røine M, Mahmoud RA, Smerud KT, Djupesland PG, Andreassen OA. Quintana DS, et al. Among authors: mahmoud ra. Transl Psychiatry. 2015 Jul 14;5(7):e602. doi: 10.1038/tp.2015.93. Transl Psychiatry. 2015. PMID: 26171983 Free PMC article. Clinical Trial.
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