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Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.
Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H. Brand S, et al. Among authors: maier t. Cell Chem Biol. 2018 Sep 20;25(9):1095-1106.e23. doi: 10.1016/j.chembiol.2018.05.016. Epub 2018 Jun 28. Cell Chem Biol. 2018. PMID: 30251630 Free article.
Celecoxib inhibits 5-lipoxygenase.
Maier TJ, Tausch L, Hoernig M, Coste O, Schmidt R, Angioni C, Metzner J, Groesch S, Pergola C, Steinhilber D, Werz O, Geisslinger G. Maier TJ, et al. Biochem Pharmacol. 2008 Oct 1;76(7):862-72. doi: 10.1016/j.bcp.2008.07.009. Epub 2008 Jul 19. Biochem Pharmacol. 2008. PMID: 18692027
Cellular membranes function as a storage compartment for celecoxib.
Maier TJ, Schiffmann S, Wobst I, Birod K, Angioni C, Hoffmann M, Lopez JJ, Glaubitz C, Steinhilber D, Geisslinger G, Grösch S. Maier TJ, et al. J Mol Med (Berl). 2009 Oct;87(10):981-93. doi: 10.1007/s00109-009-0506-8. Epub 2009 Jul 30. J Mol Med (Berl). 2009. PMID: 19641861
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.
Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ. Steinbrink SD, et al. Cell Mol Life Sci. 2010 Mar;67(5):797-806. doi: 10.1007/s00018-009-0206-0. Epub 2009 Nov 29. Cell Mol Life Sci. 2010. PMID: 20091083
A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm.
Revermann M, Mieth A, Popescu L, Paulke A, Wurglics M, Pellowska M, Fischer AS, Steri R, Maier TJ, Schermuly RT, Geisslinger G, Schubert-Zsilavecz M, Brandes RP, Steinhilber D. Revermann M, et al. Among authors: maier tj. Br J Pharmacol. 2011 Aug;163(8):1721-32. doi: 10.1111/j.1476-5381.2011.01321.x. Br J Pharmacol. 2011. PMID: 21410457 Free PMC article.
763 results