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Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate.
Maini RN, Taylor PC, Szechinski J, Pavelka K, Bröll J, Balint G, Emery P, Raemen F, Petersen J, Smolen J, Thomson D, Kishimoto T; CHARISMA Study Group. Maini RN, et al. Arthritis Rheum. 2006 Sep;54(9):2817-29. doi: 10.1002/art.22033. Arthritis Rheum. 2006. PMID: 16947782 Free article. Clinical Trial.
Infliximab in active early rheumatoid arthritis.
Breedveld FC, Emery P, Keystone E, Patel K, Furst DE, Kalden JR, St Clair EW, Weisman M, Smolen J, Lipsky PE, Maini RN. Breedveld FC, et al. Ann Rheum Dis. 2004 Feb;63(2):149-55. doi: 10.1136/ard.2003.013961. Ann Rheum Dis. 2004. PMID: 14722203 Free PMC article. Clinical Trial.
Anti-TNF alpha therapy in rheumatoid arthritis--current and future directions.
Taylor PC, Williams RO, Maini RN. Taylor PC, et al. Curr Dir Autoimmun. 2000;2:83-102. doi: 10.1159/000060499. Curr Dir Autoimmun. 2000. PMID: 11791460 Review. No abstract available.
Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
Maini RN, Taylor PC, Paleolog E, Charles P, Ballara S, Brennan FM, Feldmann M. Maini RN, et al. Ann Rheum Dis. 1999 Nov;58 Suppl 1(Suppl 1):I56-60. doi: 10.1136/ard.58.2008.i56. Ann Rheum Dis. 1999. PMID: 10577974 Free PMC article. Review. No abstract available.
The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Feldmann M, Bondeson J, Brennan FM, Foxwell BM, Maini RN. Feldmann M, et al. Ann Rheum Dis. 1999 Nov;58 Suppl 1(Suppl 1):I27-31. doi: 10.1136/ard.58.2008.i27. Ann Rheum Dis. 1999. PMID: 10577970 Free PMC article. Review.
Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.
Charles P, Elliott MJ, Davis D, Potter A, Kalden JR, Antoni C, Breedveld FC, Smolen JS, Eberl G, deWoody K, Feldmann M, Maini RN. Charles P, et al. J Immunol. 1999 Aug 1;163(3):1521-8. J Immunol. 1999. PMID: 10415055 Clinical Trial.
Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases.
Feldman M, Taylor P, Paleolog E, Brennan FM, Maini RN. Feldman M, et al. Transplant Proc. 1998 Dec;30(8):4126-7. doi: 10.1016/s0041-1345(98)01365-7. Transplant Proc. 1998. PMID: 9865320 Review. No abstract available.
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