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Page 1
Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster DT, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Ušaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chalmers JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Echenique JIR, Gacesa R, Farias AG, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim HJ, Lin K, Lu X, Maier M, Nami B, Nixon A, Mikolajewicz N, Mokhtaridoost M, Nedyalkova L, Rohde T, Rodrigues MS, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Taylor DT, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Maass PG, Reversade B, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: mair b. Cell. 2026 Apr 27:S0092-8674(26)00345-4. doi: 10.1016/j.cell.2026.03.044. Online ahead of print. Cell. 2026. PMID: 42049019 Free article.
Genetic dependencies associated with transcription factor activities in human cancer cell lines.
Thatikonda V, Supper V, Wachter J, Kaya O, Kombara A, Bilgilier C, Ravichandran MC, Lipp JJ, Sharma R, Badertscher L, Boghossian AS, Rees MG, Ronan MM, Roth JA, Grosche S, Neumüller RA, Mair B, Mauri F, Popa A. Thatikonda V, et al. Among authors: mair b. Cell Rep. 2024 May 28;43(5):114175. doi: 10.1016/j.celrep.2024.114175. Epub 2024 Apr 30. Cell Rep. 2024. PMID: 38691456 Free article.
Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.
Billmann M, Costanzo M, Rahman M, Chan K, Yan Tong AH, Ward HN, Hassan AZ, Zhang X, Brown KR, Rohde T, Shaw AH, Ross C, van Leeuwen J, Aregger M, Lawson K, Mair B, Mero P, Usaj M, Andrews B, Boone C, Moffat J, Myers CL. Billmann M, et al. Among authors: mair b. bioRxiv [Preprint]. 2026 Jan 5:2025.06.30.662330. doi: 10.1101/2025.06.30.662330. bioRxiv. 2026. PMID: 41542642 Free PMC article. Preprint.
Toward Brain NaV1.8 Imaging with [11C]Suzetrigine.
Tokala R, Pearson TD, Mair BA, Bricault S, Wallace R, Wey HY, Hooker JM, Lee SJ. Tokala R, et al. Among authors: mair ba. Pharmaceuticals (Basel). 2025 Nov 28;18(12):1816. doi: 10.3390/ph18121816. Pharmaceuticals (Basel). 2025. PMID: 41471305 Free PMC article.
A global genetic interaction map of a human cell reveals conserved principles of genetic networks.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster D, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Usaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Rojas Echenique JI, Gacesa R, Granda Farias A, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim J, Lin K, Lu X, Nami B, Nixon A, Mikolajewicz N, Nedyalkova L, Rohde T, Sartori Rodrigues M, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Thomson Taylor D, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: mair b. bioRxiv [Preprint]. 2025 Jul 2:2025.06.30.662193. doi: 10.1101/2025.06.30.662193. bioRxiv. 2025. PMID: 40631273 Free PMC article. Preprint.
SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRASG12D inhibitor in KRAS LUAD.
Baltanás FC, Kramer-Drauberg M, García-Navas R, Patrucco E, Petrini E, Arnhof H, Olarte-San Juan A, Rodríguez-Ramos P, Borrajo J, Calzada N, Castellano E, Mair B, Kostyrko K, Hofmann MH, Ambrogio C, Santos E. Baltanás FC, et al. Among authors: mair b. Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2422943122. doi: 10.1073/pnas.2422943122. Epub 2025 Mar 12. Proc Natl Acad Sci U S A. 2025. PMID: 40073053 Free PMC article.
SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma.
Daley BR, Sealover NE, Sheffels E, Hughes JM, Gerlach D, Hofmann MH, Kostyrko K, Mair B, Linke A, Beckley Z, Frank A, Dalgard C, Kortum RL. Daley BR, et al. Among authors: mair b. bioRxiv [Preprint]. 2023 Dec 15:2023.12.07.570642. doi: 10.1101/2023.12.07.570642. bioRxiv. 2023. Update in: Cancer Res. 2025 Jan 2;85(1):118-133. doi: 10.1158/0008-5472.CAN-23-3256. PMID: 38106234 Free PMC article. Updated. Preprint.
63 results