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The G4 genome.
Maizels N, Gray LT. Maizels N, et al. PLoS Genet. 2013 Apr;9(4):e1003468. doi: 10.1371/journal.pgen.1003468. Epub 2013 Apr 18. PLoS Genet. 2013. PMID: 23637633 Free PMC article.
Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways.
Olson HC, Davis L, Kiianitsa K, Khoo KJ, Liu Y, Knijnenburg TA, Maizels N. Olson HC, et al. Among authors: maizels n. Nucleic Acids Res. 2018 Oct 12;46(18):9496-9509. doi: 10.1093/nar/gky727. Nucleic Acids Res. 2018. PMID: 30107528 Free PMC article.
Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.
Nguyen GH, Tang W, Robles AI, Beyer RP, Gray LT, Welsh JA, Schetter AJ, Kumamoto K, Wang XW, Hickson ID, Maizels N, Monnat RJ Jr, Harris CC. Nguyen GH, et al. Among authors: maizels n. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9905-10. doi: 10.1073/pnas.1404807111. Epub 2014 Jun 23. Proc Natl Acad Sci U S A. 2014. PMID: 24958861 Free PMC article.
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks.
Kuhar R, Gwiazda KS, Humbert O, Mandt T, Pangallo J, Brault M, Khan I, Maizels N, Rawlings DJ, Scharenberg AM, Certo MT. Kuhar R, et al. Among authors: maizels n. Nucleic Acids Res. 2014 Jan;42(1):e4. doi: 10.1093/nar/gkt872. Epub 2013 Oct 10. Nucleic Acids Res. 2014. PMID: 24121685 Free PMC article.
A rapid and sensitive assay for DNA-protein covalent complexes in living cells.
Kiianitsa K, Maizels N. Kiianitsa K, et al. Among authors: maizels n. Nucleic Acids Res. 2013 May;41(9):e104. doi: 10.1093/nar/gkt171. Epub 2013 Mar 21. Nucleic Acids Res. 2013. PMID: 23519618 Free PMC article.
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes.
Eddy J, Maizels N. Eddy J, et al. Among authors: maizels n. Nucleic Acids Res. 2008 Mar;36(4):1321-33. doi: 10.1093/nar/gkm1138. Epub 2008 Jan 10. Nucleic Acids Res. 2008. PMID: 18187510 Free PMC article.
G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition.
Huber MD, Lee DC, Maizels N. Huber MD, et al. Among authors: maizels n. Nucleic Acids Res. 2002 Sep 15;30(18):3954-61. doi: 10.1093/nar/gkf530. Nucleic Acids Res. 2002. PMID: 12235379 Free PMC article.
We identify the porphyrin N-methyl mesoporphyrin IX (NMM) as a specific inhibitor of G4 DNA unwinding, and show that in the presence of NMM the helicase becomes trapped on the NMM-G4 DNA complex, consuming ATP but unable to unwind or dissociate. ...
We identify the porphyrin N-methyl mesoporphyrin IX (NMM) as a specific inhibitor of G4 DNA unwinding, and show that in the presence …
Two Distinct Pathways Support Gene Correction by Single-Stranded Donors at DNA Nicks.
Davis L, Maizels N. Davis L, et al. Among authors: maizels n. Cell Rep. 2016 Nov 8;17(7):1872-1881. doi: 10.1016/j.celrep.2016.10.049. Cell Rep. 2016. PMID: 27829157 Free PMC article.
DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.
Sacho EJ, Maizels N. Sacho EJ, et al. Among authors: maizels n. J Biol Chem. 2011 Dec 30;286(52):44945-51. doi: 10.1074/jbc.M111.299347. Epub 2011 Oct 28. J Biol Chem. 2011. PMID: 22039049 Free PMC article.
G4 DNA: at risk in the genome.
Davis L, Maizels N. Davis L, et al. Among authors: maizels n. EMBO J. 2011 Oct 5;30(19):3878-9. doi: 10.1038/emboj.2011.342. EMBO J. 2011. PMID: 21975374 Free PMC article.
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