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Tolerance, not immunity, crucially depends on IL-2.
Malek TR, Bayer AL. Malek TR, et al. Nat Rev Immunol. 2004 Sep;4(9):665-74. doi: 10.1038/nri1435. Nat Rev Immunol. 2004. PMID: 15343366 Review.
IL7Rα contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages.
Ashbaugh JJ, Brambilla R, Karmally SA, Cabello C, Malek TR, Bethea JR. Ashbaugh JJ, et al. J Immunol. 2013 May 1;190(9):4525-34. doi: 10.4049/jimmunol.1203214. Epub 2013 Mar 25. J Immunol. 2013. PMID: 23530149 Free PMC article.
The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development.
Castro I, Yu A, Dee MJ, Malek TR. Castro I, et al. J Immunol. 2011 Nov 15;187(10):5170-82. doi: 10.4049/jimmunol.1003961. Epub 2011 Oct 7. J Immunol. 2011. PMID: 21984699 Free PMC article.
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