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Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease.
Chance JP, Fejzic H, Hernandez O, Istvan ES, Andaya A, Maslov N, Aispuro R, Crisanto T, Nguyen H, Vidal B, Serrano W, Kuwahara B, Pugne Andanado C, Goldberg DE, Mallari JP. Chance JP, et al. Among authors: mallari jp. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1846-1848. doi: 10.1016/j.bmcl.2018.04.010. Epub 2018 Apr 19. Bioorg Med Chem Lett. 2018. PMID: 29691139
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: mallari jp. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423
Structure guided development of potent piperazine-derived hydroxamic acid inhibitors targeting falcilysin.
Kahlon G, Lira R, Masvlov N, Pompa E, Brar N, Eagon S, Anderson MO, Andaya A, Chance JP, Fejzic H, Keniston A, Huynh N, Celis N, Vidal B, Trieu N, Rodriguez P, Mallari JP. Kahlon G, et al. Among authors: mallari jp. Bioorg Med Chem Lett. 2021 Jan 15;32:127683. doi: 10.1016/j.bmcl.2020.127683. Epub 2020 Nov 20. Bioorg Med Chem Lett. 2021. PMID: 33227414 Free article.
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