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A genome annotation-driven approach to cloning the human ORFeome.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I. Collins JE, et al. Genome Biol. 2004;5(10):R84. doi: 10.1186/gb-2004-5-10-r84. Epub 2004 Sep 30. Genome Biol. 2004. PMID: 15461802 Free PMC article.
Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design.
Gooptu B, Miranda E, Nobeli I, Mallya M, Purkiss A, Brown SC, Summers C, Phillips RL, Lomas DA, Barrett TE. Gooptu B, et al. Among authors: mallya m. J Mol Biol. 2009 Apr 10;387(4):857-68. doi: 10.1016/j.jmb.2009.01.069. Epub 2009 Feb 14. J Mol Biol. 2009. PMID: 19232354 Free PMC article.
Molecular mousetraps and the serpinopathies.
Lomas DA, Belorgey D, Mallya M, Miranda E, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Robertson AS, Crowther DC. Lomas DA, et al. Biochem Soc Trans. 2005 Apr;33(Pt 2):321-30. doi: 10.1042/BST0330321. Biochem Soc Trans. 2005. PMID: 15787598
Members of the serine proteinase inhibitor or serpin superfamily inhibit their target proteinases by a remarkable conformational transition that involves the enzyme being translocated more than 70 A (1 A = 10(-10) m) from the upper to the lower pole of the inhibitor. ...
Members of the serine proteinase inhibitor or serpin superfamily inhibit their target proteinases by a remarkable conformational transition …
Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.
Mallya M, Phillips RL, Saldanha SA, Gooptu B, Brown SC, Termine DJ, Shirvani AM, Wu Y, Sifers RN, Abagyan R, Lomas DA. Mallya M, et al. J Med Chem. 2007 Nov 1;50(22):5357-63. doi: 10.1021/jm070687z. Epub 2007 Oct 5. J Med Chem. 2007. PMID: 17918823 Free PMC article.
Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.
Lomas DA, Belorgey D, Mallya M, Onda M, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Crowther DC, Miranda E. Lomas DA, et al. Front Biosci. 2004 Sep 1;9:2873-91. doi: 10.2741/1444. Front Biosci. 2004. PMID: 15353322 Review.
Differential detection of PAS-positive inclusions formed by the Z, Siiyama, and Mmalton variants of alpha1-antitrypsin.
Janciauskiene S, Eriksson S, Callea F, Mallya M, Zhou A, Seyama K, Hata S, Lomas DA. Janciauskiene S, et al. Hepatology. 2004 Nov;40(5):1203-10. doi: 10.1002/hep.20451. Hepatology. 2004. PMID: 15486938
Polymers of plasma M and Z alpha(1)-antitrypsin prepared under different conditions in vitro and polymers of recombinant mutants of alpha(1)-antitrypsin demonstrated that the monoclonal antibody detected a neoepitope on the polymerized protein. ...
Polymers of plasma M and Z alpha(1)-antitrypsin prepared under different conditions in vitro and polymers of recombinant mutants of a …
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