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Comparative biodistribution of imaging agents for in vivo molecular profiling of disseminated prostate cancer in mice bearing prostate cancer xenografts: focus on 111In- and 125I-labeled anti-HER2 humanized monoclonal trastuzumab and ABY-025 affibody.
Malmberg J, Sandström M, Wester K, Tolmachev V, Orlova A. Malmberg J, et al. Nucl Med Biol. 2011 Nov;38(8):1093-102. doi: 10.1016/j.nucmedbio.2011.04.005. Epub 2011 Jun 22. Nucl Med Biol. 2011. PMID: 22137850
Imaging agents for in vivo molecular profiling of disseminated prostate cancer: Cellular processing of [(111)In]-labeled CHX-A″DTPA-trastuzumab and anti-HER2 ABY-025 Affibody in prostate cancer cell lines.
Malmberg J, Tolmachev V, Orlova A. Malmberg J, et al. Exp Ther Med. 2011 May;2(3):523-528. doi: 10.3892/etm.2011.217. Epub 2011 Feb 22. Exp Ther Med. 2011. PMID: 22977535 Free PMC article.
Evaluation of backbone-cyclized HER2-binding 2-helix affibody molecule for in vivo molecular imaging.
Honarvar H, Jokilaakso N, Andersson K, Malmberg J, Rosik D, Orlova A, Karlström AE, Tolmachev V, Järver P. Honarvar H, et al. Nucl Med Biol. 2013 Apr;40(3):378-86. doi: 10.1016/j.nucmedbio.2012.12.009. Epub 2013 Jan 26. Nucl Med Biol. 2013. PMID: 23357083
Development of a 124I-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer: Aspects of labeling chemistry and biodistribution.
Tolmachev V, Malmberg J, Estrada S, Eriksson O, Orlova A. Tolmachev V, et al. Int J Oncol. 2014 Jun;44(6):1998-2008. doi: 10.3892/ijo.2014.2376. Epub 2014 Apr 10. Int J Oncol. 2014. PMID: 24718894
HAHAHA, HEHEHE, HIHIHI, or HKHKHK: influence of position and composition of histidine containing tags on biodistribution of [(99m)Tc(CO)3](+)-labeled affibody molecules.
Hofström C, Altai M, Honarvar H, Strand J, Malmberg J, Hosseinimehr SJ, Orlova A, Gräslund T, Tolmachev V. Hofström C, et al. J Med Chem. 2013 Jun 27;56(12):4966-74. doi: 10.1021/jm400218y. Epub 2013 Jun 14. J Med Chem. 2013. PMID: 23692562
Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts.
Malmberg J, Perols A, Varasteh Z, Altai M, Braun A, Sandström M, Garske U, Tolmachev V, Orlova A, Karlström AE. Malmberg J, et al. Eur J Nucl Med Mol Imaging. 2012 Mar;39(3):481-92. doi: 10.1007/s00259-011-1992-9. Epub 2011 Nov 30. Eur J Nucl Med Mol Imaging. 2012. PMID: 22322933
Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the affibody molecule 111In-DOTA-ZIGF1R:4551.
Tolmachev V, Malmberg J, Hofström C, Abrahmsén L, Bergman T, Sjöberg A, Sandström M, Gräslund T, Orlova A. Tolmachev V, et al. J Nucl Med. 2012 Jan;53(1):90-7. doi: 10.2967/jnumed.111.090829. Epub 2011 Dec 15. J Nucl Med. 2012. PMID: 22173843
Direct comparison of 111In-labelled two-helix and three-helix Affibody molecules for in vivo molecular imaging.
Rosik D, Orlova A, Malmberg J, Altai M, Varasteh Z, Sandström M, Karlström AE, Tolmachev V. Rosik D, et al. Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):693-702. doi: 10.1007/s00259-011-2016-5. Epub 2011 Dec 15. Eur J Nucl Med Mol Imaging. 2012. PMID: 22170322
Molecular design and optimization of 99mTc-labeled recombinant affibody molecules improves their biodistribution and imaging properties.
Wållberg H, Orlova A, Altai M, Hosseinimehr SJ, Widström C, Malmberg J, Ståhl S, Tolmachev V. Wållberg H, et al. J Nucl Med. 2011 Mar;52(3):461-9. doi: 10.2967/jnumed.110.083592. Epub 2011 Feb 14. J Nucl Med. 2011. PMID: 21321280
HEHEHE-tagged affibody molecule may be purified by IMAC, is conveniently labeled with [⁹⁹(m)Tc(CO)₃](+), and shows improved biodistribution with reduced hepatic radioactivity accumulation.
Tolmachev V, Hofström C, Malmberg J, Ahlgren S, Hosseinimehr SJ, Sandström M, Abrahmsén L, Orlova A, Gräslund T. Tolmachev V, et al. Bioconjug Chem. 2010 Nov 17;21(11):2013-22. doi: 10.1021/bc1002357. Epub 2010 Oct 22. Bioconjug Chem. 2010. PMID: 20964447
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