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The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces.
Fernández-Moreno MA, Caballero JL, Hopwood DA, Malpartida F. Fernández-Moreno MA, et al. Cell. 1991 Aug 23;66(4):769-80. doi: 10.1016/0092-8674(91)90120-n. Cell. 1991. PMID: 1878971
The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis.
Seco EM, Miranzo D, Nieto C, Malpartida F. Seco EM, et al. Appl Microbiol Biotechnol. 2010 Feb;85(6):1797-807. doi: 10.1007/s00253-009-2193-3. Epub 2009 Aug 26. Appl Microbiol Biotechnol. 2010. PMID: 19707755
Isolation and characterization of pcsB, the gene for a polyene carboxamide synthase that tailors pimaricin into AB-400.
Miranzo D, Seco EM, Cuesta T, Malpartida F. Miranzo D, et al. Appl Microbiol Biotechnol. 2010 Feb;85(6):1809-19. doi: 10.1007/s00253-009-2195-1. Epub 2009 Aug 26. Appl Microbiol Biotechnol. 2010. PMID: 19707754
Heterologous activation of the actinorhodin biosynthetic pathway in Streptomyces lividans.
Romero NM, Parro V, Malpartida F, Mellado RP. Romero NM, et al. Nucleic Acids Res. 1992 Jun 11;20(11):2767-72. doi: 10.1093/nar/20.11.2767. Nucleic Acids Res. 1992. PMID: 1614864 Free PMC article.
Genetic and biochemical characterization of the red gene cluster of Streptomyces coelicolor A3(2).
Feitelson JS, Malpartida F, Hopwood DA. Feitelson JS, et al. J Gen Microbiol. 1985 Sep;131(9):2431-41. doi: 10.1099/00221287-131-9-2431. J Gen Microbiol. 1985. PMID: 2999302
Four red genes (redA, B, E, and F) were mapped to different regions within the cloned DNA. Screening with redE probes for DNA homologies among various streptomycetes revealed hybridizing DNA in three strains, one of them not known to synthesize prodigiosin pigments. ...
Four red genes (redA, B, E, and F) were mapped to different regions within the cloned DNA. Screening with redE probes for DNA homolog …
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