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Page 1
Dual-Site Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach.
Malune P, Iaconis D, Manelfi C, Giunta S, Emmolo R, Lunghini F, Paulis A, Talarico C, Corona A, Beccari AR, Tramontano E, Esposito F. Malune P, et al. ACS Infect Dis. 2025 Oct 10;11(10):2821-2835. doi: 10.1021/acsinfecdis.5c00517. Epub 2025 Sep 26. ACS Infect Dis. 2025. PMID: 41002177 Free PMC article.
The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors.
Zian D, Iaconis D, Nenci S, Crusco A, Tawde S, Sodano M, Vitalone R, Raje A, Palamini M, Carettoni D, Molteni A, Manelfi C, Tazzari V, Beccari AR, Malune P, Maloccu S, Paulis A, Corona A, Nieddu S, Coletti S, Scarabottolo L, Tramontano E, Esposito F, Catalani M. Zian D, et al. Among authors: malune p. Antiviral Res. 2025 May;237:106119. doi: 10.1016/j.antiviral.2025.106119. Epub 2025 Feb 18. Antiviral Res. 2025. PMID: 39978553 Free article.
Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity.
Iacobucci I, Cipollone I, Cozzolino F, Iaconis D, Talarico C, Coppola G, Morasso S, Costanzi E, Malune P, Storici P, Tramontano E, Esposito F, Monti M. Iacobucci I, et al. Among authors: malune p. Int J Biol Macromol. 2025 Mar;295:139590. doi: 10.1016/j.ijbiomac.2025.139590. Epub 2025 Jan 7. Int J Biol Macromol. 2025. PMID: 39788258 Free article.
New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors.
Messore A, Malune P, Patacchini E, Madia VN, Ialongo D, Arpacioglu M, Albano A, Ruggieri G, Saccoliti F, Scipione L, Tramontano E, Canton S, Corona A, Scognamiglio S, Paulis A, Suleiman M, Al-Maqtari HM, Abid FMA, Kawsar SMA, Sankaranarayanan M, Di Santo R, Esposito F, Costi R. Messore A, et al. Among authors: malune p. Pharmaceuticals (Basel). 2024 May 17;17(5):650. doi: 10.3390/ph17050650. Pharmaceuticals (Basel). 2024. PMID: 38794220 Free PMC article.
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex.
Kuzikov M, Reinshagen J, Wycisk K, Corona A, Esposito F, Malune P, Manelfi C, Iaconis D, Beccari A, Tramontano E, Nowotny M, Windshügel B, Gribbon P, Zaliani A. Kuzikov M, et al. Among authors: malune p. Virus Res. 2024 May;343:199356. doi: 10.1016/j.virusres.2024.199356. Epub 2024 Mar 16. Virus Res. 2024. PMID: 38490582 Free PMC article.
Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro.
Biolatti M, Blangetti M, Baggieri M, Marchi A, Gioacchini S, Bajetto G, Arnodo D, Bucci P, Fioravanti R, Kojouri M, Bersani M, D'Arrigo G, Siragusa L, Ghinato S, De Andrea M, Gugliesi F, Albano C, Pasquero S, Visentin I, D'Ugo E, Esposito F, Malune P, Tramontano E, Prandi C, Spyrakis F, Magurano F, Dell'Oste V. Biolatti M, et al. Among authors: malune p. ACS Infect Dis. 2023 Jul 14;9(7):1310-1318. doi: 10.1021/acsinfecdis.3c00219. Epub 2023 Jun 26. ACS Infect Dis. 2023. PMID: 37358826