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Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A. Sasaki A, et al. Nat Cell Biol. 2003 May;5(5):427-32. doi: 10.1038/ncb978. Nat Cell Biol. 2003. PMID: 12717443
Here we show that mammalian Sprouty4 suppresses vascular epithelial growth factor (VEGF)-induced, Ras-independent activation of Raf1 but does not affect epidermal growth factor (EGF)-induced, Ras-dependent activation
Here we show that mammalian Sprouty4 suppresses vascular epithelial growth factor (VEGF)-induced, Ras-indepen