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1990 1
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2008 2
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89 results

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Page 1
Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.
Clain JA, Picard M, Rabezanahary H, André S, Boutrais S, Goma Matsetse E, Dewatines J, Dueymes Q, Thiboutot E, Racine G, Soundaramourty C, Mammano F, Corbeau P, Zghidi-Abouzid O, Estaquier J. Clain JA, et al. Among authors: mammano f. Infect Dis Rep. 2025 Feb 6;17(1):12. doi: 10.3390/idr17010012. Infect Dis Rep. 2025. PMID: 39997464 Free PMC article. Review.
BACKGROUND/OBJECTIVES: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection. METHODS: By using non-human primate models of pathogenic and non-pathogenic …
BACKGROUND/OBJECTIVES: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events assoc …
Hyperthermia stimulates HIV-1 replication.
Roesch F, Meziane O, Kula A, Nisole S, Porrot F, Anderson I, Mammano F, Fassati A, Marcello A, Benkirane M, Schwartz O. Roesch F, et al. Among authors: mammano f. PLoS Pathog. 2012;8(7):e1002792. doi: 10.1371/journal.ppat.1002792. Epub 2012 Jul 12. PLoS Pathog. 2012. PMID: 22807676 Free PMC article.
In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription.
Ay S, Burlaud-Gaillard J, Gazi A, Tatirovsky Y, Cuche C, Diana JS, Scoca V, Di Santo JP, Roingeard P, Mammano F, Di Nunzio F. Ay S, et al. Among authors: mammano f. EMBO J. 2025 Jan;44(1):166-199. doi: 10.1038/s44318-024-00316-w. Epub 2024 Dec 2. EMBO J. 2025. PMID: 39623137 Free PMC article.
Our functional analyses showed that HIV-1-MLOs remained stable during treatment with a reverse transcriptase inhibitor, maintaining the virus in a dormant state. Drug withdrawal restored reverse transcription, promoting efficient virus replication akin to that obser …
Our functional analyses showed that HIV-1-MLOs remained stable during treatment with a reverse transcriptase inhibitor, maintaining the v …
HIV drug resistance and viral fitness.
Clavel F, Race E, Mammano F. Clavel F, et al. Among authors: mammano f. Adv Pharmacol. 2000;49:41-66. doi: 10.1016/s1054-3589(00)49023-x. Adv Pharmacol. 2000. PMID: 11013760 Review. No abstract available.
T cell apoptosis characterizes severe Covid-19 disease.
André S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butaux A, Soundaramourty C, Cruz AS, Mendes-Frias A, Gotti C, Leclercq M, Nicolas A, Tauzin A, Carvalho A, Capela C, Pedrosa J, Castro AG, Kundura L, Loubet P, Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Racine G, Zghidi-Abouzid O, Nioche P, Silvestre R, Droit A, Mammano F, Corbeau P, Estaquier J. André S, et al. Among authors: mammano f. Cell Death Differ. 2022 Aug;29(8):1486-1499. doi: 10.1038/s41418-022-00936-x. Epub 2022 Jan 22. Cell Death Differ. 2022. PMID: 35066575 Free PMC article.
Connexin hemichannel blockade by abEC1.1 disrupts glioblastoma progression, suppresses invasiveness, and reduces hyperexcitability in preclinical models.
Donati V, Di Pietro C, Persano L, Rampazzo E, Panarelli M, Cambria C, Selimi A, Manfreda L, de Oliveira do Rêgo AG, La Sala G, Sprega C, Calistri A, Ciubotaru CD, Yang G, Zonta F, Antonucci F, Marazziti D, Mammano F. Donati V, et al. Among authors: mammano f. Cell Commun Signal. 2025 Sep 2;23(1):391. doi: 10.1186/s12964-025-02370-1. Cell Commun Signal. 2025. PMID: 40898342 Free PMC article.
METHODS: The efficacy of abEC1.1, a monoclonal antibody that inhibits Cx26, Cx30, and Cx32 HCs, was assessed in vitro by measuring invasion capability, dye and Ca(2+) uptake, glutamate and ATP release in patient-derived GBM cultures or organoids. Adeno-associated virus (AA …
METHODS: The efficacy of abEC1.1, a monoclonal antibody that inhibits Cx26, Cx30, and Cx32 HCs, was assessed in vitro by measuring invasion …
Neutralizing antibodies and restriction factors cooperatively exert selective pressure on the HIV-1 envelope glycoprotein.
Marceau T, Migraine J, Moreau A, Arrouche Y, Andriantsoanirina V, Verrier B, Mammano F, Meyer L, Braibant M. Marceau T, et al. Among authors: mammano f. AIDS. 2025 Oct 1;39(12):1699-1708. doi: 10.1097/QAD.0000000000004304. Epub 2025 Jul 17. AIDS. 2025. PMID: 40705005
The study focused on evaluating the sensitivity of these variants to three restriction factors and their susceptibility to neutralization by autologous antibodies and human monoclonal antibodies (HuMobNAbs). METHODS: Env-pseudotyped viruses were generated by co-transfectin …
The study focused on evaluating the sensitivity of these variants to three restriction factors and their susceptibility to neutralization by …
Innate sensing of HIV-infected cells.
Lepelley A, Louis S, Sourisseau M, Law HK, Pothlichet J, Schilte C, Chaperot L, Plumas J, Randall RE, Si-Tahar M, Mammano F, Albert ML, Schwartz O. Lepelley A, et al. Among authors: mammano f. PLoS Pathog. 2011 Feb;7(2):e1001284. doi: 10.1371/journal.ppat.1001284. Epub 2011 Feb 17. PLoS Pathog. 2011. PMID: 21379343 Free PMC article.
Donor cells expressing replication-defective viruses, carrying mutated reverse transcriptase, integrase or nucleocapsid proteins induced IFN production by target cells as potently as wild-type virus. ...
Donor cells expressing replication-defective viruses, carrying mutated reverse transcriptase, integrase or nucleocapsid proteins indu …
Hypoxia-inducible factor 2 triggers the production of highly infectious native-like hepatitis C virus particles.
Couteaudier M, Nivard M, Cochard J, Mammano F, Roingeard P, de Rocquigny H, Chouteau P. Couteaudier M, et al. Among authors: mammano f. Cell Mol Life Sci. 2025 Jun 19;82(1):241. doi: 10.1007/s00018-025-05739-0. Cell Mol Life Sci. 2025. PMID: 40533570 Free PMC article.
In HCV-infected siHIF-2alpha Hypo-Diff cells, both HCV replication and the specific infectious viral efficacy of progeny viruses were significantly impaired. Interestingly, the ectopic expression of a mutated form of the HIF-2alpha protein, stabilized in normoxia, both inc …
In HCV-infected siHIF-2alpha Hypo-Diff cells, both HCV replication and the specific infectious viral efficacy of progeny viruses were …
Genotypic and Phenotypic Diversity of the Replication-Competent HIV Reservoir in Treated Patients.
Nicolas A, Migraine J, Dutrieux J, Salmona M, Tauzin A, Hachiya A, Estaquier J, Molina JM, Clavel F, Hance AJ, Mammano F. Nicolas A, et al. Among authors: mammano f. Microbiol Spectr. 2022 Aug 31;10(4):e0078422. doi: 10.1128/spectrum.00784-22. Epub 2022 Jun 30. Microbiol Spectr. 2022. PMID: 35770985 Free PMC article.
Between 4 and 14 (mean, 8) individual viral isolates per patient were obtained using a virus outgrowth assay, and their near-full-length genomes were sequenced. The mean pairwise distance (MPD) observed in different patients correlated with the time before undetectable vir …
Between 4 and 14 (mean, 8) individual viral isolates per patient were obtained using a virus outgrowth assay, and their near-full-len …
89 results