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Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion.
Greco AV, Mingrone G, Giancaterini A, Manco M, Morroni M, Cinti S, Granzotto M, Vettor R, Camastra S, Ferrannini E. Greco AV, et al. Diabetes. 2002 Jan;51(1):144-51. doi: 10.2337/diabetes.51.1.144. Diabetes. 2002. PMID: 11756334
Whole-body insulin sensitivity (by the insulin clamp technique), intramyocellular lipids (by quantitative histochemistry on quadriceps muscle biopsies), muscle insulin action (as the expression of Glut4 glucose transporters), and postprandial lipemia were measured in 20 morbidly …
Whole-body insulin sensitivity (by the insulin clamp technique), intramyocellular lipids (by quantitative histochemistry on quadriceps muscl …
Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity.
Mingrone G, Rosa G, Greco AV, Manco M, Vega N, Nanni G, Castagneto M, Vidal H. Mingrone G, et al. Atherosclerosis. 2003 Sep;170(1):155-61. doi: 10.1016/s0021-9150(03)00254-5. Atherosclerosis. 2003. PMID: 12957694
Insulin sensitivity (M/I) was assessed by euglycemic-hyperinsulinemic clamp. Energy expenditure and respiratory quotient (RQ) were measured over 24 h in a calorimetric chamber. ...The M/I value was normalized after surgery (0.036+/-0.0148 to 0.095+/-0.0147 micromol …
Insulin sensitivity (M/I) was assessed by euglycemic-hyperinsulinemic clamp. Energy expenditure and respiratory quotient (RQ) were me …
Menopause, insulin resistance, and risk factors for cardiovascular disease.
Manco M, Nolfe G, Calvani M, Natali A, Nolan J, Ferrannini E, Mingrone G; European Group for the Study of Insulin Resistance. Manco M, et al. Menopause. 2006 Sep-Oct;13(5):809-17. doi: 10.1097/01.gme.0000233492.38638.74. Menopause. 2006. PMID: 16900080
DESIGN: Information was obtained on whole-body glucose uptake (M), determined by the euglycemic hyperinsulinemic clamp technique, normalized by fat-free mass (FFM), and insulin concentration (I) at a steady state. ...RESULTS: M/kg(FFM)/I significantly decreased afte …
DESIGN: Information was obtained on whole-body glucose uptake (M), determined by the euglycemic hyperinsulinemic clamp technique, nor …
Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women.
Manco M, Fernandez-Real JM, Equitani F, Vendrell J, Valera Mora ME, Nanni G, Tondolo V, Calvani M, Ricart W, Castagneto M, Mingrone G. Manco M, et al. J Clin Endocrinol Metab. 2007 Feb;92(2):483-90. doi: 10.1210/jc.2006-0960. Epub 2006 Nov 14. J Clin Endocrinol Metab. 2007. PMID: 17105839
Glucose sensitivity (M value) was estimated using the euglycemic-hyperinsulinemic clamp. Mannan-binding lectin (MBL), bactericidal/permeability increasing protein (BPI), alpha-defensins, soluble CD14 receptor (sCD14), C-reactive protein, adiponectin, leptin, visfatin, IL-6 …
Glucose sensitivity (M value) was estimated using the euglycemic-hyperinsulinemic clamp. Mannan-binding lectin (MBL), bactericidal/pe …
Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon?
Manco M, Fernández-Real JM, Valera-Mora ME, Déchaud H, Nanni G, Tondolo V, Calvani M, Castagneto M, Pugeat M, Mingrone G. Manco M, et al. Diabetes Care. 2007 Jun;30(6):1494-500. doi: 10.2337/dc06-1353. Diabetes Care. 2007. PMID: 17526821

Insulin secretion decreased (52.04 +/- 16.71 vs. 30.62 +/- 16.32 nmol/m(-2); P < or = 0.05), and insulin sensitivity increased by 163% (P < or = 0.0001). Serum CBG was related to BMI (r(0) = 0.708; P = 0.0001), body weight (r(0) = 0.643; P = 0.0001), body fat percent

Insulin secretion decreased (52.04 +/- 16.71 vs. 30.62 +/- 16.32 nmol/m(-2); P < or = 0.05), and insulin sensitivity increased by

Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis.
Manco M, Marcellini M, Devito R, Comparcola D, Sartorelli MR, Nobili V. Manco M, et al. Int J Obes (Lond). 2008 Feb;32(2):381-7. doi: 10.1038/sj.ijo.0803711. Epub 2007 Dec 18. Int J Obes (Lond). 2008. PMID: 18087267
Insulin resistance and exercise capacity in male children and adolescents with non-alcholic fatty liver disease.
Manco M, Giordano U, Turchetta A, Fruhwirth R, Ancinelli M, Marcellini M, Nobili V. Manco M, et al. Acta Diabetol. 2009 Jun;46(2):97-104. doi: 10.1007/s00592-008-0063-6. Epub 2008 Oct 7. Acta Diabetol. 2009. PMID: 18839055
Nonalcoholic fatty liver disease in children.
Manco M, Bottazzo G, DeVito R, Marcellini M, Mingrone G, Nobili V. Manco M, et al. J Am Coll Nutr. 2008 Dec;27(6):667-76. doi: 10.1080/07315724.2008.10719744. J Am Coll Nutr. 2008. PMID: 19155426 Review.
Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects.
Brufani C, Tozzi A, Fintini D, Ciampalini P, Grossi A, Fiori R, Kiepe D, Manco M, Schiaffini R, Porzio O, Cappa M, Barbetti F. Brufani C, et al. Eur J Endocrinol. 2009 May;160(5):769-75. doi: 10.1530/EJE-08-0878. Epub 2009 Feb 16. Eur J Endocrinol. 2009. PMID: 19221173
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