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Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases.
Weinreb O, Mandel S, Amit T, Youdim MB. Weinreb O, et al. J Nutr Biochem. 2004 Sep;15(9):506-16. doi: 10.1016/j.jnutbio.2004.05.002. J Nutr Biochem. 2004. PMID: 15350981 Review.
As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson' …
As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to …
The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice.
Mechlovich D, Amit T, Bar-Am O, Mandel S, Youdim MB, Weinreb O. Mechlovich D, et al. Curr Alzheimer Res. 2014 Feb;11(2):119-27. doi: 10.2174/1567205010666131212112529. Curr Alzheimer Res. 2014. PMID: 24359498
Increasing evidence suggests that dysregulation of brain insulin/insulin receptor (InsR) and insulin signaling cascade are associated with the pathogenesis of Alzheimer's disease (AD). ...
Increasing evidence suggests that dysregulation of brain insulin/insulin receptor (InsR) and insulin signaling cascade are associated with t …
Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration.
Kupershmidt L, Okun Z, Amit T, Mandel S, Saltsman I, Mahammed A, Bar-Am O, Gross Z, Youdim MB. Kupershmidt L, et al. J Neurochem. 2010 Apr;113(2):363-73. doi: 10.1111/j.1471-4159.2010.06619.x. Epub 2010 Jan 24. J Neurochem. 2010. PMID: 20096090
The relevance of iron in the pathogenesis of Parkinson's disease.
Sian-Hülsmann J, Mandel S, Youdim MB, Riederer P. Sian-Hülsmann J, et al. J Neurochem. 2011 Sep;118(6):939-57. doi: 10.1111/j.1471-4159.2010.07132.x. Epub 2011 Jan 31. J Neurochem. 2011. PMID: 21138437 Review.
Alterations of iron levels in the brain has been observed and documented in a number of neurodegenerative disorders including Parkinson's disease (PD). ...
Alterations of iron levels in the brain has been observed and documented in a number of neurodegenerative disorders including Parkinson's
Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators.
Weinreb O, Mandel S, Youdim MBH, Amit T. Weinreb O, et al. Free Radic Biol Med. 2013 Sep;62:52-64. doi: 10.1016/j.freeradbiomed.2013.01.017. Epub 2013 Jan 30. Free Radic Biol Med. 2013. PMID: 23376471 Review.
Brain iron accumulation has been implicated in a host of chronic neurological diseases, including Parkinson's disease (PD). The elevated iron levels observed in the substantia nigra of PD subjects have been suggested to incite the generation of reactive oxygen species and …
Brain iron accumulation has been implicated in a host of chronic neurological diseases, including Parkinson's disease (PD). The eleva …
Novel therapeutic approach for neurodegenerative pathologies: multitarget iron-chelating drugs regulating hypoxia-inducible factor 1 signal transduction pathway.
Weinreb O, Amit T, Mandel S, Youdim MB. Weinreb O, et al. Neurodegener Dis. 2012;10(1-4):112-5. doi: 10.1159/000332597. Epub 2011 Dec 9. Neurodegener Dis. 2012. PMID: 22156453 Review.
Our novel multimodal brain-permeable iron-chelating compounds M30 and HLA20 were demonstrated to possess neuroprotective/neurorescue activities in vitro and in vivo against several insults applicable to various neurodegenerative diseases, such as Alzheimer's disease, Parki …
Our novel multimodal brain-permeable iron-chelating compounds M30 and HLA20 were demonstrated to possess neuroprotective/neurorescue activit …
Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs.
Weinreb O, Mandel S, Bar-Am O, Yogev-Falach M, Avramovich-Tirosh Y, Amit T, Youdim MB. Weinreb O, et al. Neurotherapeutics. 2009 Jan;6(1):163-74. doi: 10.1016/j.nurt.2008.10.030. Neurotherapeutics. 2009. PMID: 19110207 Free PMC article. Review.
Preclinical experiments showed that both compounds have anti-Alzheimer's disease activities and thus, the clinical development is oriented toward treatment of this type of dementia. ...Altogether, these scientific findings make these multifunctional compounds potentially v …
Preclinical experiments showed that both compounds have anti-Alzheimer's disease activities and thus, the clinical development is ori …
Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs.
Mandel S, Weinreb O, Youdim MB. Mandel S, et al. Drug Discov Today. 2004 Dec 15;9(24 Suppl):S37-44. Drug Discov Today. 2004. PMID: 23573659
The remarkable progress made by molecular biology and molecular genetics during the past decade, and the advent of the novel tools of genomics and proteomics, are expected to reveal differential expression profiles of thousands of genes and proteins involved in the degeneration o …
The remarkable progress made by molecular biology and molecular genetics during the past decade, and the advent of the novel tools of genomi …
Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
Bar-Am O, Amit T, Weinreb O, Youdim MB, Mandel S. Bar-Am O, et al. J Alzheimers Dis. 2010;21(2):361-71. doi: 10.3233/JAD-2010-100150. J Alzheimers Dis. 2010. PMID: 20555137 Review.
This indication and recent therapeutic approaches, entailing new drug candidates possessing diverse pharmacological properties and acting on multiple targets, have stimulated the development of two multifunctional chimeric propargylamine-derivatives: 1) ladostigil (TV3326, [(N-pr …
This indication and recent therapeutic approaches, entailing new drug candidates possessing diverse pharmacological properties and acting on …
Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators.
Amit T, Avramovich-Tirosh Y, Youdim MB, Mandel S. Amit T, et al. FASEB J. 2008 May;22(5):1296-305. doi: 10.1096/fj.07-8627rev. Epub 2007 Nov 29. FASEB J. 2008. PMID: 18048580 Review.
Dysregulation of brain iron homeostasis is central to early neuropathological events in Alzheimer's disease (AD), including oxidative stress, inflammatory processes, amyloid deposition, tau phosphorylation, and neuronal cell cycle regulatory failure, leading to apoptosis. …
Dysregulation of brain iron homeostasis is central to early neuropathological events in Alzheimer's disease (AD), including oxidative …
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