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Microtubules and microtubule-associated proteins.
Mandelkow E, Mandelkow EM. Mandelkow E, et al. Among authors: mandelkow em. Curr Opin Cell Biol. 1995 Feb;7(1):72-81. doi: 10.1016/0955-0674(95)80047-6. Curr Opin Cell Biol. 1995. PMID: 7755992 Review.
Tau in physiology and pathology.
Wang Y, Mandelkow E. Wang Y, et al. Among authors: mandelkow e. Nat Rev Neurosci. 2016 Jan;17(1):5-21. doi: 10.1038/nrn.2015.1. Epub 2015 Dec 3. Nat Rev Neurosci. 2016. PMID: 26631930 Review.
The Binding Mode of a Tau Peptide with Tubulin.
Kadavath H, Cabrales Fontela Y, Jaremko M, Jaremko Ł, Overkamp K, Biernat J, Mandelkow E, Zweckstetter M. Kadavath H, et al. Among authors: mandelkow e. Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3246-3250. doi: 10.1002/anie.201712089. Epub 2018 Feb 22. Angew Chem Int Ed Engl. 2018. PMID: 29314492
Atypical, non-standard functions of the microtubule associated Tau protein.
Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, Blum D, Sayas CL, Mandelkow EM, Mandelkow E, Spillantini MG, Sousa N, Avila J, Medina M, Mudher A, Buee L. Sotiropoulos I, et al. Among authors: mandelkow em, mandelkow e. Acta Neuropathol Commun. 2017 Nov 29;5(1):91. doi: 10.1186/s40478-017-0489-6. Acta Neuropathol Commun. 2017. PMID: 29187252 Free PMC article. Review.
Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and envir …
Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic tar …
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.
Ambadipudi S, Biernat J, Riedel D, Mandelkow E, Zweckstetter M. Ambadipudi S, et al. Among authors: mandelkow e. Nat Commun. 2017 Aug 17;8(1):275. doi: 10.1038/s41467-017-00480-0. Nat Commun. 2017. PMID: 28819146 Free PMC article.
Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.
Schwalbe M, Biernat J, Bibow S, Ozenne V, Jensen MR, Kadavath H, Blackledge M, Mandelkow E, Zweckstetter M. Schwalbe M, et al. Among authors: mandelkow e. Biochemistry. 2013 Dec 17;52(50):9068-79. doi: 10.1021/bi401266n. Epub 2013 Nov 22. Biochemistry. 2013. PMID: 24251416
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.
Zempel H, Luedtke J, Kumar Y, Biernat J, Dawson H, Mandelkow E, Mandelkow EM. Zempel H, et al. Among authors: mandelkow e, mandelkow em. EMBO J. 2013 Nov 13;32(22):2920-37. doi: 10.1038/emboj.2013.207. Epub 2013 Sep 24. EMBO J. 2013. PMID: 24065130 Free PMC article.
Biochemistry and cell biology of tau protein in neurofibrillary degeneration.
Mandelkow EM, Mandelkow E. Mandelkow EM, et al. Among authors: mandelkow e. Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006247. doi: 10.1101/cshperspect.a006247. Cold Spring Harb Perspect Med. 2012. PMID: 22762014 Free PMC article. Review.
Hsp90-Tau complex reveals molecular basis for specificity in chaperone action.
Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG. Karagöz GE, et al. Among authors: mandelkow e. Cell. 2014 Feb 27;156(5):963-74. doi: 10.1016/j.cell.2014.01.037. Cell. 2014. PMID: 24581495 Free PMC article.
The dynamic structure of filamentous tau.
Bibow S, Mukrasch MD, Chinnathambi S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. Bibow S, et al. Among authors: mandelkow e. Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11520-4. doi: 10.1002/anie.201105493. Epub 2011 Oct 11. Angew Chem Int Ed Engl. 2011. PMID: 21990182 No abstract available.
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