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FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments.
Kaniyappan S, Tepper K, Biernat J, Chandupatla RR, Hübschmann S, Irsen S, Bicher S, Klatt C, Mandelkow EM, Mandelkow E. Kaniyappan S, et al. Among authors: mandelkow em. Mol Neurodegener. 2020 Jul 16;15(1):39. doi: 10.1186/s13024-020-00389-1. Mol Neurodegener. 2020. PMID: 32677995 Free PMC article.
Presynaptic Pathophysiology Encoded in Different Domains of Tau - Hyper-Versus Hypoexcitability?
Decker JM, Mandelkow EM. Decker JM, et al. Among authors: mandelkow em. Adv Exp Med Biol. 2019;1184:97-103. doi: 10.1007/978-981-32-9358-8_8. Adv Exp Med Biol. 2019. PMID: 32096031 Review.
Engineered antibodies: new possibilities for brain PET?
Sehlin D, Syvänen S; MINC faculty. Sehlin D, et al. Eur J Nucl Med Mol Imaging. 2019 Dec;46(13):2848-2858. doi: 10.1007/s00259-019-04426-0. Epub 2019 Jul 24. Eur J Nucl Med Mol Imaging. 2019. PMID: 31342134 Free PMC article. Review.
Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model.
Green C, Sydow A, Vogel S, Anglada-Huguet M, Wiedermann D, Mandelkow E, Mandelkow EM, Hoehn M. Green C, et al. Among authors: mandelkow em. Mol Neurodegener. 2019 Mar 27;14(1):13. doi: 10.1186/s13024-019-0316-6. Mol Neurodegener. 2019. PMID: 30917861 Free PMC article.
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.
Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow EM, Encalada SE, Kao AW. Butler VJ, et al. Among authors: mandelkow em. Hum Mol Genet. 2019 May 1;28(9):1498-1514. doi: 10.1093/hmg/ddy442. Hum Mol Genet. 2019. PMID: 30590647 Free PMC article.
Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment.
Pir GJ, Choudhary B, Kaniyappan S, Chandupatla RR, Mandelkow E, Mandelkow EM, Wang Y. Pir GJ, et al. Among authors: mandelkow em. Mol Neurobiol. 2019 May;56(5):3751-3767. doi: 10.1007/s12035-018-1326-z. Epub 2018 Sep 8. Mol Neurobiol. 2019. PMID: 30196394 Free PMC article.
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems.
Balaji V, Kaniyappan S, Mandelkow E, Wang Y, Mandelkow EM. Balaji V, et al. Among authors: mandelkow em. Autophagy. 2018;14(12):2139-2154. doi: 10.1080/15548627.2018.1509607. Epub 2018 Sep 13. Autophagy. 2018. PMID: 30145931 Free PMC article.
Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation.
Choudhary B, Mandelkow E, Mandelkow EM, Pir GJ. Choudhary B, et al. Among authors: mandelkow em. Neurobiol Dis. 2018 Sep;117:189-202. doi: 10.1016/j.nbd.2018.06.005. Epub 2018 Jun 9. Neurobiol Dis. 2018. PMID: 29894752
Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes.
Mari SA, Wegmann S, Tepper K, Hyman BT, Mandelkow EM, Mandelkow E, Müller DJ. Mari SA, et al. Among authors: mandelkow em. Nano Lett. 2018 May 9;18(5):3271-3281. doi: 10.1021/acs.nanolett.8b01085. Epub 2018 Apr 17. Nano Lett. 2018. PMID: 29644863 Free PMC article.
What is the evidence that tau pathology spreads through prion-like propagation?
Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Alavi Naini SM, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP. Mudher A, et al. Among authors: mandelkow em. Acta Neuropathol Commun. 2017 Dec 19;5(1):99. doi: 10.1186/s40478-017-0488-7. Acta Neuropathol Commun. 2017. PMID: 29258615 Free PMC article. Review.
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