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Adaptive designs for dual-agent phase I dose-escalation studies.
Harrington JA, Wheeler GM, Sweeting MJ, Mander AP, Jodrell DI. Harrington JA, et al. Nat Rev Clin Oncol. 2013 May;10(5):277-88. doi: 10.1038/nrclinonc.2013.35. Epub 2013 Mar 19. Nat Rev Clin Oncol. 2013. PMID: 23507740 Review.
A phase 2 study of vatalanib in metastatic melanoma patients.
Cook N, Basu B, Biswas S, Kareclas P, Mann C, Palmer C, Thomas A, Nicholson S, Morgan B, Lomas D, Sirohi B, Mander AP, Middleton M, Corrie PG. Cook N, et al. Eur J Cancer. 2010 Oct;46(15):2671-3. doi: 10.1016/j.ejca.2010.07.014. Epub 2010 Aug 25. Eur J Cancer. 2010. PMID: 20800475 Clinical Trial.
Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.
Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F, Walton MK, Biggs K, Nicholl J, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG. Dimairo M, et al. Among authors: mander ap. BMC Med. 2018 Nov 16;16(1):210. doi: 10.1186/s12916-018-1196-2. BMC Med. 2018. PMID: 30442137 Free PMC article.
Assessment of cognitive safety in clinical drug development.
Roiser JP, Nathan PJ, Mander AP, Adusei G, Zavitz KH, Blackwell AD. Roiser JP, et al. Drug Discov Today. 2016 Mar;21(3):445-53. doi: 10.1016/j.drudis.2015.11.003. Epub 2015 Nov 22. Drug Discov Today. 2016. PMID: 26610416 Free PMC article. Review.
A Bayesian model-free approach to combination therapy phase I trials using censored time-to-toxicity data.
Wheeler GM, Sweeting MJ, Mander AP. Wheeler GM, et al. Among authors: mander ap. J R Stat Soc Ser C Appl Stat. 2019 Feb;68(2):309-329. doi: 10.1111/rssc.12323. Epub 2018 Nov 22. J R Stat Soc Ser C Appl Stat. 2019. PMID: 30880843 Free PMC article.
An optimised multi-arm multi-stage clinical trial design for unknown variance.
Grayling MJ, Wason JMS, Mander AP. Grayling MJ, et al. Contemp Clin Trials. 2018 Apr;67:116-120. doi: 10.1016/j.cct.2018.02.011. Epub 2018 Feb 21. Contemp Clin Trials. 2018. PMID: 29474933 Free PMC article.
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