Mandine E - Search Results

1

Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein.

Deprez P, Mandine E, Gofflo D, Meunier S, Lesuisse D. Deprez P, et al. Among authors: mandine e. Bioorg Med Chem Lett. 2002 May 6;12(9):1295-8. doi: 10.1016/s0960-894x(02)00140-3. Bioorg Med Chem Lett. 2002. PMID: 11965374

2

Imidazole-based ligands of the Src SH2 protein.

Deprez P, Mandine E, Vermond A, Lesuisse D. Deprez P, et al. Among authors: mandine e. Bioorg Med Chem Lett. 2002 May 6;12(9):1287-9. doi: 10.1016/s0960-894x(02)00138-5. Bioorg Med Chem Lett. 2002. PMID: 11965372

3

Discovery of highly potent Src SH2 binders: structure-activity studies and X-ray structures.

Deprez P, Baholet I, Burlet S, Lange G, Amengual R, Schoot B, Vermond A, Mandine E, Lesuisse D. Deprez P, et al. Among authors: mandine e. Bioorg Med Chem Lett. 2002 May 6;12(9):1291-4. doi: 10.1016/s0960-894x(02)00139-7. Bioorg Med Chem Lett. 2002. PMID: 11965373

4

SAR and X-ray. A new approach combining fragment-based screening and rational drug design: application to the discovery of nanomolar inhibitors of Src SH2.

Lesuisse D, Lange G, Deprez P, Bénard D, Schoot B, Delettre G, Marquette JP, Broto P, Jean-Baptiste V, Bichet P, Sarubbi E, Mandine E. Lesuisse D, et al. Among authors: mandine e. J Med Chem. 2002 Jun 6;45(12):2379-87. doi: 10.1021/jm010927p. J Med Chem. 2002. PMID: 12036348

5

Principles governing the binding of a class of non-peptidic inhibitors to the SH2 domain of src studied by X-ray analysis.

Lange G, Lesuisse D, Deprez P, Schoot B, Loenze P, Bénard D, Marquette JP, Broto P, Sarubbi E, Mandine E. Lange G, et al. Among authors: mandine e. J Med Chem. 2002 Jul 4;45(14):2915-22. doi: 10.1021/jm0110800. J Med Chem. 2002. PMID: 12086479

6

High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system.

Mandine E, Jean-Baptiste V, Vayssière B, Gofflo D, Bénard D, Sarubbi E, Deprez P, Baron R, Superti-Furga G, Lesuisse D. Mandine E, et al. Biochem Biophys Res Commun. 2002 Oct 25;298(2):185-92. doi: 10.1016/s0006-291x(02)02424-5. Biochem Biophys Res Commun. 2002. PMID: 12387813

7

Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.

Lange G, Lesuisse D, Deprez P, Schoot B, Loenze P, Bénard D, Marquette JP, Broto P, Sarubbi E, Mandine E. Lange G, et al. Among authors: mandine e. J Med Chem. 2003 Nov 20;46(24):5184-95. doi: 10.1021/jm020970s. J Med Chem. 2003. PMID: 14613321

8

Src homology-2 domain binding assays by scintillation proximity and surface plasmon resonance.

Mandine E, Gofflo D, Jean-Baptiste V, Sarubbi E, Touyer G, Deprez P, Lesuisse D. Mandine E, et al. J Mol Recognit. 2001 Jul-Aug;14(4):254-60. doi: 10.1002/jmr.542. J Mol Recognit. 2001. PMID: 11500972

9

Discovery of thioazepinone ligands for Src SH2: from non-specific to specific binding.

Lesuisse D, Deprez P, Albert E, Duc TT, Sortais B, Gofflo D, Jean-Baptiste V, Marquette J, Schoot B, Sarubbi E, Lange G, Broto P, Mandine E. Lesuisse D, et al. Among authors: mandine e. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2127-31. doi: 10.1016/s0960-894x(01)00386-9. Bioorg Med Chem Lett. 2001. PMID: 11514153

10

Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.

Violette SM, Guan W, Bartlett C, Smith JA, Bardelay C, Antoine E, Rickles RJ, Mandine E, van Schravendijk MR, Adams SE, Lynch BA, Shakespeare WC, Yang M, Jacobsen VA, Takeuchi CS, Macek KJ, Bohacek RS, Dalgarno DC, Weigele M, Lesuisse D, Sawyer TK, Baron R. Violette SM, et al. Among authors: mandine e. Bone. 2001 Jan;28(1):54-64. doi: 10.1016/s8756-3282(00)00427-0. Bone. 2001. PMID: 11165943

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