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Mechanisms of tamoxifen-induced apoptosis.
Mandlekar S, Kong AN. Mandlekar S, et al. Apoptosis. 2001 Dec;6(6):469-77. doi: 10.1023/a:1012437607881. Apoptosis. 2001. PMID: 11595837 Review.
Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines.
Mandlekar S, Hebbar V, Christov K, Kong AN. Mandlekar S, et al. Cancer Res. 2000 Dec 1;60(23):6601-6. Cancer Res. 2000. PMID: 11118041
We showed that the s.c. injection of 1 mg/kg TAM in adult female Sprague Dawley rats bearing carcinogen-induced mammary tumors resulted in rapid serum decline of parent TAM but higher exposure of the metabolites, OHT and DMT. ...
We showed that the s.c. injection of 1 mg/kg TAM in adult female Sprague Dawley rats bearing carcinogen-induced mammary tumors result …
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.
Mandlekar S, Yu R, Tan TH, Kong AN. Mandlekar S, et al. Cancer Res. 2000 Nov 1;60(21):5995-6000. Cancer Res. 2000. PMID: 11085519
Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C.
Yu R, Mandlekar S, Tan TH, Kong AN. Yu R, et al. Among authors: mandlekar s. J Biol Chem. 2000 Mar 31;275(13):9612-9. doi: 10.1074/jbc.275.13.9612. J Biol Chem. 2000. PMID: 10734112
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.
Yu R, Mandlekar S, Ruben S, Ni J, Kong AN. Yu R, et al. Among authors: mandlekar s. Cancer Res. 2000 May 1;60(9):2384-9. Cancer Res. 2000. PMID: 10811114
Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.
Kong AN, Yu R, Chen C, Mandlekar S, Primiano T. Kong AN, et al. Among authors: mandlekar s. Arch Pharm Res. 2000 Feb;23(1):1-16. doi: 10.1007/BF02976458. Arch Pharm Res. 2000. PMID: 10728649 Review.
Signal transduction events elicited by cancer prevention compounds.
Kong AN, Yu R, Hebbar V, Chen C, Owuor E, Hu R, Ee R, Mandlekar S. Kong AN, et al. Among authors: mandlekar s. Mutat Res. 2001 Sep 1;480-481:231-41. doi: 10.1016/s0027-5107(01)00182-8. Mutat Res. 2001. PMID: 11506817 Review.
Many chemopreventive agents have been shown to modulate gene expression including induction of phase II detoxifying enzymes, such as glutathione S-transferases (GST) and quinone reductases (QR). ...
Many chemopreventive agents have been shown to modulate gene expression including induction of phase II detoxifying enzymes, such as glutath …
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.
Yu R, Hebbar V, Kim DW, Mandlekar S, Pezzuto JM, Kong AN. Yu R, et al. Among authors: mandlekar s. Mol Pharmacol. 2001 Jul;60(1):217-24. doi: 10.1124/mol.60.1.217. Mol Pharmacol. 2001. PMID: 11408617
Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.
Lei W, Yu R, Mandlekar S, Kong AN. Lei W, et al. Among authors: mandlekar s. Cancer Res. 1998 May 15;58(10):2102-6. Cancer Res. 1998. PMID: 9605752
Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals.
Yu R, Lei W, Mandlekar S, Weber MJ, Der CJ, Wu J, Kong AN. Yu R, et al. Among authors: mandlekar s. J Biol Chem. 1999 Sep 24;274(39):27545-52. doi: 10.1074/jbc.274.39.27545. J Biol Chem. 1999. PMID: 10488090
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