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Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells.
Pavlovic D, Andersen NA, Mandrup-Poulsen T, Eizirik DL. Pavlovic D, et al. Eur Cytokine Netw. 2000 Jun;11(2):267-74. Eur Cytokine Netw. 2000. PMID: 10903806
JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression.
Prause M, Mayer CM, Brorsson C, Frederiksen KS, Billestrup N, Størling J, Mandrup-Poulsen T. Prause M, et al. J Diabetes Res. 2016;2016:1312705. doi: 10.1155/2016/1312705. Epub 2016 Jan 10. J Diabetes Res. 2016. PMID: 26962537 Free PMC article.
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY. Maedler K, et al. Diabetes. 2004 Jul;53(7):1706-13. doi: 10.2337/diabetes.53.7.1706. Diabetes. 2004. PMID: 15220194
Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.
Donath MY, Størling J, Maedler K, Mandrup-Poulsen T. Donath MY, et al. J Mol Med (Berl). 2003 Aug;81(8):455-70. doi: 10.1007/s00109-003-0450-y. Epub 2003 Jul 18. J Mol Med (Berl). 2003. PMID: 12879149 Review.
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.
Zaitseva II, Sharoyko V, Størling J, Efendic S, Guerin C, Mandrup-Poulsen T, Nicotera P, Berggren PO, Zaitsev SV. Zaitseva II, et al. Biochem Biophys Res Commun. 2006 Sep 8;347(4):1121-8. doi: 10.1016/j.bbrc.2006.06.197. Epub 2006 Jul 14. Biochem Biophys Res Commun. 2006. PMID: 16870144
Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Bruun C, Heding PE, Rønn SG, Frobøse H, Rhodes CJ, Mandrup-Poulsen T, Billestrup N. Bruun C, et al. Mol Cell Endocrinol. 2009 Nov 13;311(1-2):32-8. doi: 10.1016/j.mce.2009.07.019. Epub 2009 Jul 28. Mol Cell Endocrinol. 2009. PMID: 19643162
Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Størling J, Zaitsev SV, Kapelioukh IL, Karlsen AE, Billestrup N, Berggren PO, Mandrup-Poulsen T. Størling J, et al. Endocrinology. 2005 Jul;146(7):3026-36. doi: 10.1210/en.2005-0036. Epub 2005 Apr 14. Endocrinology. 2005. PMID: 15831571
Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis.
Ghiasi SM, Dahllöf MS, Osmai Y, Osmai M, Jakobsen KK, Aivazidis A, Tyrberg B, Perruzza L, Prause MCB, Christensen DP, Fog-Tonnesen M, Lundh M, Grassi F, Chatenoud L, Mandrup-Poulsen T. Ghiasi SM, et al. Mol Cell Endocrinol. 2018 Dec 15;478:106-114. doi: 10.1016/j.mce.2018.08.001. Epub 2018 Aug 16. Mol Cell Endocrinol. 2018. PMID: 30121202
TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells.
Prause M, Berchtold LA, Urizar AI, Hyldgaard Trauelsen M, Billestrup N, Mandrup-Poulsen T, Størling J. Prause M, et al. Mol Cell Endocrinol. 2016 Jan 15;420:24-36. doi: 10.1016/j.mce.2015.11.021. Epub 2015 Nov 22. Mol Cell Endocrinol. 2016. PMID: 26610752
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL. Ortis F, et al. Mol Endocrinol. 2006 Aug;20(8):1867-79. doi: 10.1210/me.2005-0268. Epub 2006 Mar 23. Mol Endocrinol. 2006. PMID: 16556731
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