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Kinetic target-guided synthesis.
Hu X, Manetsch R. Hu X, et al. Among authors: manetsch r. Chem Soc Rev. 2010 Apr;39(4):1316-24. doi: 10.1039/b904092g. Epub 2010 Feb 2. Chem Soc Rev. 2010. PMID: 20309488 Review.
Going beyond Binary: Rapid Identification of Protein-Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach.
Nacheva K, Kulkarni SS, Kassu M, Flanigan D, Monastyrskyi A, Iyamu ID, Doi K, Barber M, Namelikonda N, Tipton JD, Parvatkar P, Wang HG, Manetsch R. Nacheva K, et al. Among authors: manetsch r. J Med Chem. 2023 Apr 13;66(7):5196-5207. doi: 10.1021/acs.jmedchem.3c00108. Epub 2023 Mar 31. J Med Chem. 2023. PMID: 37000900 Free PMC article.
Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases.
Kassu M, Parvatkar PT, Milanes J, Monaghan NP, Kim C, Dowgiallo M, Zhao Y, Asakawa AH, Huang L, Wagner A, Miller B, Carter K, Barrett KF, Tillery LM, Barrett LK, Phan IQ, Subramanian S, Myler PJ, Van Voorhis WC, Leahy JW, Rice CA, Kyle DE, Morris J, Manetsch R. Kassu M, et al. Among authors: manetsch r. ACS Infect Dis. 2023 Nov 10;9(11):2190-2201. doi: 10.1021/acsinfecdis.3c00284. Epub 2023 Oct 11. ACS Infect Dis. 2023. PMID: 37820055 Free PMC article.
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