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Phase I trial of intravesical recombinant adenovirus mediated interferon-α2b formulated in Syn3 for Bacillus Calmette-Guérin failures in nonmuscle invasive bladder cancer.
Dinney CP, Fisher MB, Navai N, O'Donnell MA, Cutler D, Abraham A, Young S, Hutchins B, Caceres M, Kishnani N, Sode G, Cullen C, Zhang G, Grossman HB, Kamat AM, Gonzales M, Kincaid M, Ainslie N, Maneval DC, Wszolek MF, Benedict WF. Dinney CP, et al. Among authors: maneval dc. J Urol. 2013 Sep;190(3):850-6. doi: 10.1016/j.juro.2013.03.030. Epub 2013 Mar 15. J Urol. 2013. PMID: 23507396 Free PMC article. Clinical Trial.
Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein.
Benedict WF, Tao Z, Kim CS, Zhang X, Zhou JH, Adam L, McConkey DJ, Papageorgiou A, Munsell M, Philopena J, Engler H, Demers W, Maneval DC, Dinney CP, Connor RJ. Benedict WF, et al. Among authors: maneval dc. Mol Ther. 2004 Sep;10(3):525-32. doi: 10.1016/j.ymthe.2004.05.027. Mol Ther. 2004. PMID: 15336652
Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation.
Kuball J, Wen SF, Leissner J, Atkins D, Meinhardt P, Quijano E, Engler H, Hutchins B, Maneval DC, Grace MJ, Fritz MA, Störkel S, Thüroff JW, Huber C, Schuler M. Kuball J, et al. Among authors: maneval dc. J Clin Oncol. 2002 Feb 15;20(4):957-65. doi: 10.1200/JCO.2002.20.4.957. J Clin Oncol. 2002. PMID: 11844817 Clinical Trial.
Enhancement of adenovirus-mediated gene transfer to human bone marrow cells.
Watanabe T, Kelsey L, Ageitos A, Kuszynski C, Ino K, Heimann DG, Varney MT, Shepard HM, Vaillancourt MT, Maneval DC, Talmadge JE. Watanabe T, et al. Among authors: maneval dc. Leuk Lymphoma. 1998 May;29(5-6):439-51. doi: 10.3109/10428199809050904. Leuk Lymphoma. 1998. PMID: 9643558
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