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Page 1
Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity.
Tooley K, Jerby L, Escobar G, Krovi SH, Mangani D, Dandekar G, Cheng H, Madi A, Goldschmidt E, Lambden C, Krishnan RK, Rozenblatt-Rosen O, Regev A, Anderson AC. Tooley K, et al. Among authors: mangani d. Cell Rep Med. 2024 Jul 16;5(7):101640. doi: 10.1016/j.xcrm.2024.101640. Epub 2024 Jul 2. Cell Rep Med. 2024. PMID: 38959885 Free PMC article.
Dietary protein modulates intestinal dendritic cells to establish mucosal homeostasis.
Moreira TG, Cox LM, Da Silva P, Mangani D, De Oliveira MG, Escobar G, Lanser TB, Murphy L, Lobo ELC, Milstein O, Gauthier CD, Clara Guimarāes A, Schwerdtfeger L, Ekwudo MN, Wasén C, Liu S, Menezes GB, Ferreira E, Gabriely G, Anderson AC, Faria AMC, Rezende RM, Weiner HL. Moreira TG, et al. Among authors: mangani d. Mucosal Immunol. 2024 Oct;17(5):911-922. doi: 10.1016/j.mucimm.2024.06.006. Epub 2024 Jun 24. Mucosal Immunol. 2024. PMID: 38925529 Free article.
A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance.
Mertens RT, Misra A, Xiao P, Baek S, Rone JM, Mangani D, Sivanathan KN, Arojojoye AS, Awuah SG, Lee I, Shi GP, Petrova B, Brook JR, Anderson AC, Flavell RA, Kanarek N, Hemberg M, Nowarski R. Mertens RT, et al. Among authors: mangani d. Immunity. 2024 Sep 10;57(9):2077-2094.e12. doi: 10.1016/j.immuni.2024.06.001. Epub 2024 Jun 20. Immunity. 2024. PMID: 38906145
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.
Cadinu P, Sivanathan KN, Misra A, Xu RJ, Mangani D, Yang E, Rone JM, Tooley K, Kye YC, Bod L, Geistlinger L, Lee T, Mertens RT, Ono N, Wang G, Sanmarco L, Quintana FJ, Anderson AC, Kuchroo VK, Moffitt JR, Nowarski R. Cadinu P, et al. Among authors: mangani d. Cell. 2024 Apr 11;187(8):2010-2028.e30. doi: 10.1016/j.cell.2024.03.013. Epub 2024 Apr 2. Cell. 2024. PMID: 38569542
Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy.
Escobar G, Tooley K, Oliveras JP, Huang L, Cheng H, Bookstaver ML, Edwards C, Froimchuk E, Xue C, Mangani D, Krishnan RK, Hazel N, Rutigliani C, Jewell CM, Biasco L, Anderson AC. Escobar G, et al. Among authors: mangani d. Cancer Cell. 2023 Sep 11;41(9):1662-1679.e7. doi: 10.1016/j.ccell.2023.08.001. Epub 2023 Aug 24. Cancer Cell. 2023. PMID: 37625402 Free PMC article.
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.
Cadinu P, Sivanathan KN, Misra A, Xu RJ, Mangani D, Yang E, Rone JM, Tooley K, Kye YC, Bod L, Geistlinger L, Lee T, Ono N, Wang G, Sanmarco L, Quintana FJ, Anderson AC, Kuchroo VK, Moffitt JR, Nowarski R. Cadinu P, et al. Among authors: mangani d. bioRxiv [Preprint]. 2023 May 9:2023.05.08.539701. doi: 10.1101/2023.05.08.539701. bioRxiv. 2023. Update in: Cell. 2024 Apr 11;187(8):2010-2028.e30. doi: 10.1016/j.cell.2024.03.013. PMID: 37214800 Free PMC article. Updated. Preprint.
Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19.
G Moreira T, Gauthier CD, Murphy L, Lanser TB, Paul A, Matos KTF, Mangani D, Izzy S, Rezende RM, Healy BC, Baecher-Allan CM, Chitnis T, Kuchroo V, Weiner HL. G Moreira T, et al. Among authors: mangani d. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2220272120. doi: 10.1073/pnas.2220272120. Epub 2023 Mar 7. Proc Natl Acad Sci U S A. 2023. PMID: 36881624 Free PMC article. Clinical Trial.
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