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Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease.
Vainshtein A, Veenman L, Shterenberg A, Singh S, Masarwa A, Dutta B, Island B, Tsoglin E, Levin E, Leschiner S, Maniv I, Pe'er L, Otradnov I, Zubedat S, Aga-Mizrachi S, Weizman A, Avital A, Marek I, Gavish M. Vainshtein A, et al. Among authors: maniv i. Cell Death Discov. 2015 Nov 30;1:15027. doi: 10.1038/cddiscovery.2015.27. eCollection 2015. Cell Death Discov. 2015. PMID: 27551459 Free PMC article.