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Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE 3rd, Dowd CS. Kim P, et al. Among authors: manjunatha uh. J Med Chem. 2006 Jan 12;49(1):159-71. doi: 10.1021/jm050825p. J Med Chem. 2006. PMID: 16392800 Free PMC article.
Mycobacterium leprae is naturally resistant to PA-824.
Manjunatha UH, Lahiri R, Randhawa B, Dowd CS, Krahenbuhl JL, Barry CE 3rd. Manjunatha UH, et al. Antimicrob Agents Chemother. 2006 Oct;50(10):3350-4. doi: 10.1128/AAC.00488-06. Antimicrob Agents Chemother. 2006. PMID: 17005816 Free PMC article.
Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
Li X, Manjunatha UH, Goodwin MB, Knox JE, Lipinski CA, Keller TH, Barry CE 3rd, Dowd CS. Li X, et al. Among authors: manjunatha uh. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2256-62. doi: 10.1016/j.bmcl.2008.03.011. Epub 2008 Mar 7. Bioorg Med Chem Lett. 2008. PMID: 18358721 Free PMC article.
Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.
Kim P, Kang S, Boshoff HI, Jiricek J, Collins M, Singh R, Manjunatha UH, Niyomrattanakit P, Zhang L, Goodwin M, Dick T, Keller TH, Dowd CS, Barry CE 3rd. Kim P, et al. Among authors: manjunatha uh. J Med Chem. 2009 Mar 12;52(5):1329-44. doi: 10.1021/jm801374t. J Med Chem. 2009. PMID: 19209893 Free PMC article.
48 results