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N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1.
Murphy F, Waung J, Collins J, Arthur MJ, Nagase H, Mann D, Benyon RC, Iredale JP. Murphy F, et al. Comp Hepatol. 2004 Jan 14;3 Suppl 1(Suppl 1):S8. doi: 10.1186/1476-5926-2-S1-S8. Comp Hepatol. 2004. PMID: 14960160 Free PMC article.
Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin.
Hartland SN, Murphy F, Aucott RL, Abergel A, Zhou X, Waung J, Patel N, Bradshaw C, Collins J, Mann D, Benyon RC, Iredale JP. Hartland SN, et al. Liver Int. 2009 Aug;29(7):966-78. doi: 10.1111/j.1478-3231.2009.02070.x. Liver Int. 2009. PMID: 19580633
Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2.
Bertrand-Philippe M, Ruddell RG, Arthur MJ, Thomas J, Mungalsingh N, Mann DA. Bertrand-Philippe M, et al. J Biol Chem. 2004 Jun 4;279(23):24530-9. doi: 10.1074/jbc.M311804200. Epub 2004 Mar 29. J Biol Chem. 2004. PMID: 15051730
Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1.
Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA. Oakley F, et al. J Biol Chem. 2003 Jul 4;278(27):24359-70. doi: 10.1074/jbc.M211051200. Epub 2003 Apr 16. J Biol Chem. 2003. PMID: 12700242
Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis.
Arthur MJ, Mann DA, Iredale JP. Arthur MJ, et al. J Gastroenterol Hepatol. 1998 Sep;13(S1):S33-S38. doi: 10.1111/jgh.1998.13.s1.33. J Gastroenterol Hepatol. 1998. PMID: 28976699
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis.
Oakley F, Teoh V, Ching-A-Sue G, Bataller R, Colmenero J, Jonsson JR, Eliopoulos AG, Watson MR, Manas D, Mann DA. Oakley F, et al. Gastroenterology. 2009 Jun;136(7):2334-2344.e1. doi: 10.1053/j.gastro.2009.02.081. Epub 2009 Mar 18. Gastroenterology. 2009. PMID: 19303015
Resolving fibrosis in the diseased liver: translating the scientific promise to the clinic.
Muddu AK, Guha IN, Elsharkawy AM, Mann DA. Muddu AK, et al. Int J Biochem Cell Biol. 2007;39(4):695-714. doi: 10.1016/j.biocel.2006.10.006. Epub 2006 Oct 7. Int J Biochem Cell Biol. 2007. PMID: 17110155 Review.
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.
Oakley F, Mann J, Nailard S, Smart DE, Mungalsingh N, Constandinou C, Ali S, Wilson SJ, Millward-Sadler H, Iredale JP, Mann DA. Oakley F, et al. Am J Pathol. 2005 Mar;166(3):695-708. doi: 10.1016/s0002-9440(10)62291-2. Am J Pathol. 2005. PMID: 15743782 Free PMC article.
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