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The case for an autoimmune aetiology of type 1 diabetes.
Mannering SI, Pathiraja V, Kay TW. Mannering SI, et al. Clin Exp Immunol. 2016 Jan;183(1):8-15. doi: 10.1111/cei.12699. Epub 2015 Oct 21. Clin Exp Immunol. 2016. PMID: 26313217 Free PMC article. Review.
T lymphocytes from granulocyte colony-stimulating factor-/- mice produce large quantities of interferon-gamma in a chronic infection model.
Mannering SI, Zhan Y, Gilbertson B, Lieschke GJ, Cheers C. Mannering SI, et al. Immunology. 2000 Sep;101(1):132-9. doi: 10.1046/j.1365-2567.2000.00075.x. Immunology. 2000. PMID: 11012764 Free PMC article.
Proinsulin-a pathogenic autoantigen in type 1 diabetes.
Narendran P, Mannering SI, Harrison LC. Narendran P, et al. Autoimmun Rev. 2003 Jun;2(4):204-10. doi: 10.1016/s1568-9972(03)00009-0. Autoimmun Rev. 2003. PMID: 12848947 Review.
The insulin A-chain epitope recognized by human T cells is posttranslationally modified.
Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, Purcell AW. Mannering SI, et al. J Exp Med. 2005 Nov 7;202(9):1191-7. doi: 10.1084/jem.20051251. Epub 2005 Oct 31. J Exp Med. 2005. PMID: 16260488 Free PMC article.
Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.
Campbell PD, Estella E, Dudek NL, Jhala G, Thomas HE, Kay TW, Mannering SI. Campbell PD, et al. Hum Immunol. 2008 Sep;69(9):543-51. doi: 10.1016/j.humimm.2008.06.008. Epub 2008 Jul 17. Hum Immunol. 2008. PMID: 18639598
The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes.
Mannering SI, Pang SH, Williamson NA, Naselli G, Reynolds EC, O'Brien-Simpson NM, Purcell AW, Harrison LC. Mannering SI, et al. Clin Exp Immunol. 2009 May;156(2):226-31. doi: 10.1111/j.1365-2249.2009.03907.x. Epub 2009 Mar 9. Clin Exp Immunol. 2009. PMID: 19292763 Free PMC article.
Insulin teaches a new lesson in tolerance.
Kay TW, Krishnamurthy B, Brodnicki TC, Mannering SI. Kay TW, et al. EMBO J. 2009 Sep 16;28(18):2687-8. doi: 10.1038/emboj.2009.251. EMBO J. 2009. PMID: 19759522 Free PMC article. No abstract available.
A method for extracting tissue proteins for use in lymphocyte function assays.
Moon HC, Joffe M, Thomas HE, Kay TW, Mannering SI. Moon HC, et al. J Immunol Methods. 2010 Jul 31;359(1-2):56-60. doi: 10.1016/j.jim.2010.05.002. Epub 2010 May 12. J Immunol Methods. 2010. PMID: 20470778
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