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NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes.
Aupperle K, Bennett B, Han Z, Boyle D, Manning A, Firestein G. Aupperle K, et al. J Immunol. 2001 Feb 15;166(4):2705-11. doi: 10.4049/jimmunol.166.4.2705. J Immunol. 2001. PMID: 11160335
The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies.
Palanki MS, Erdman PE, Ren M, Suto M, Bennett BL, Manning A, Ransone L, Spooner C, Desai S, Ow A, Totsuka R, Tsao P, Toriumi W. Palanki MS, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4077-80. doi: 10.1016/j.bmcl.2003.08.047. Bioorg Med Chem Lett. 2003. PMID: 14592511
Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide].
Palanki MS, Erdman PE, Gayo-Fung LM, Shevlin GI, Sullivan RW, Goldman ME, Ransone LJ, Bennett BL, Manning AM, Suto MJ. Palanki MS, et al. J Med Chem. 2000 Oct 19;43(21):3995-4004. doi: 10.1021/jm0001626. J Med Chem. 2000. PMID: 11052805
Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells.
O'Connell MA, Bennett BL, Mercurio F, Manning AM, Mackman N. O'Connell MA, et al. J Biol Chem. 1998 Nov 13;273(46):30410-4. doi: 10.1074/jbc.273.46.30410. J Biol Chem. 1998. PMID: 9804806
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
Tak PP, Gerlag DM, Aupperle KR, van de Geest DA, Overbeek M, Bennett BL, Boyle DL, Manning AM, Firestein GS. Tak PP, et al. Arthritis Rheum. 2001 Aug;44(8):1897-907. doi: 10.1002/1529-0131(200108)44:8<1897::AID-ART328>3.0.CO;2-4. Arthritis Rheum. 2001. PMID: 11508443
Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate.
Palanki MS, Erdman PE, Manning AM, Ow A, Ransone LJ, Spooner C, Suto C, Suto M. Palanki MS, et al. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1645-8. doi: 10.1016/s0960-894x(00)00312-7. Bioorg Med Chem Lett. 2000. PMID: 10937715
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